{"doi":"10.1016/j.tvjl.2012.01.018","title":"Canine tissue-specific expression of multiple small leucine rich proteoglycans","abstract":null,"journal":"The Veterinary Journal","year":2012,"id":603181,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1547262,"name":"G.J. Culshaw","orcid":null,"position":1,"is_corresponding":false},{"id":1547263,"name":"M.-M. Liu","orcid":null,"position":2,"is_corresponding":false},{"id":1547264,"name":"C.-C. Lu","orcid":null,"position":3,"is_corresponding":false},{"id":1547266,"name":"A.T. French","orcid":null,"position":4,"is_corresponding":false},{"id":1547268,"name":"D.N. Clements","orcid":null,"position":5,"is_corresponding":false},{"id":1547270,"name":"B.M. Corcoran","orcid":null,"position":6,"is_corresponding":false},{"id":1547261,"name":"C.-H. Yang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Canine tissue-specific expression of multiple small leucine rich proteoglycans","abstract":"Small leucine rich proteoglycans (SLRPs) are important constituents of extracellular matrix (ECM) and contribute to the production, organization and remodelling of collagen and elastin through complex biological systems. The relative expression and distribution of SLRPs in a variety of different mammalian tissues is poorly characterized. The aim of this study was to map the expression of seven SLRPs (biglycan, versican, prolargin, fibromodulin, osteoglycin, decorin and lumican) in seven tissues (bone, cartilage, cruciate ligament, skin, ventricular myocardium, mitral valve and cornea) in young adult dogs using a combination of quantitative real-time PCR, immunohistochemistry and protein immunoblotting. Clear and consistent patterns of SLRP expression and distribution were identified for the seven tissues examined, with the greatest SLRP expression in cartilage, skin, cornea and mitral valve, and the least expression in myocardium. In general, lumican and prolargin had the greatest expression across the seven tissues whilst osteoglycin was the least abundantly expressed SLRP. These data provide a SLRP profile for different canine tissues which can inform future studies of SLRP expression in development and disease.","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22365843","pmcid":null,"openalex_id":"https://openalex.org/W2022393093","authors":[],"funders":[],"total_grants":0,"fwci":0.7742,"citation_percentile":0.67150699,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2021,"count":3},{"year":2023,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1090023312000366?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1090023312000366?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tvjl.2012.01.018","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22365843","host_type":"repository"},{"url":"https://eprints.gla.ac.uk/78497/","host_type":"journal"}],"fields_of_study":["Proteoglycans and glycosaminoglycans research","Cell Adhesion Molecules Research","Veterinary Equine Medical Research","Animals","Blotting, Western","Dogs","Female","Gene Expression Regulation","Immunohistochemistry","Male","Organ Specificity","Polymerase Chain Reaction","Proteoglycans"],"mesh_terms":["Animals","Dogs","Female","Gene Expression Regulation","Immunohistochemistry","Male","Organ Specificity","Proteoglycans","Blotting, Western","Polymerase Chain Reaction"],"keywords":["Lumican","Biglycan","Versican","Decorin","Extracellular matrix","Proteoglycan","Elastin","Cartilage","Pathology","Fibrocartilage","Aggrecan","Cell biology","Anatomy","ADAMTS","Biology","Immunohistochemistry","Matrix metalloproteinase","Metalloproteinase","Osteoarthritis","Articular cartilage","Medicine","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T21:18:28.211877Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}