{"doi":"10.1016/j.tvjl.2004.11.017","title":"Characterisation of transthyretin and retinol-binding protein in plasma and cerebrospinal fluid of dogs","abstract":null,"journal":"The Veterinary Journal","year":2006,"id":685446,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1790787,"name":"Jens Raila","orcid":null,"position":1,"is_corresponding":false},{"id":1790788,"name":"Franck Forterre","orcid":null,"position":2,"is_corresponding":false},{"id":1790789,"name":"Leo Brunnberg","orcid":null,"position":3,"is_corresponding":false},{"id":1790790,"name":"Florian J. Schweigert","orcid":null,"position":4,"is_corresponding":false},{"id":1790786,"name":"Simone Forterre","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Characterisation of transthyretin and retinol-binding protein in plasma and cerebrospinal fluid of dogs","abstract":"The aim of this study was to investigate differences in concentrations of vitamin A, transthyretin (TTR) and retinol-binding protein (RBP) between plasma and cerebrospinal fluid (CSF) in dogs. RBP was detected using ELISA, and both RBP and TTR by Western blot analysis after separation on SDS-PAGE. Vitamin A was determined by high performance liquid chromatography. RBP and TTR as well as vitamin A were detected in all samples but at substantially lower concentrations in CSF compared to plasma. RBP in dog plasma showed a similar molecular mass to that of humans, whereas canine TTR had a lower molecular mass. Comparison between plasma and CSF showed that both RBP and TTR were of lower molecular mass in CSF. In CSF, RBP and retinol were present at 10-100-fold lower concentrations compared to plasma. Retinyl esters were present only in minute amounts in 5/17 samples. In conclusion, the CSF of dogs compared to humans is significantly different in terms of both quality and quantity of transport proteins for vitamin A.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16624711","pmcid":null,"openalex_id":"https://openalex.org/W1979449219","authors":[],"funders":[],"total_grants":0,"fwci":0.1188,"citation_percentile":0.46388464,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2021,"count":1},{"year":2023,"count":1}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://boris.unibe.ch/18841/","host_type":"repository"},{"url":"https://boris.unibe.ch/18841/","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1090023304002588?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1090023304002588?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tvjl.2004.11.017","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16624711","host_type":"repository"},{"url":"https://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/12089","host_type":"repository"}],"fields_of_study":["Retinoids in leukemia and cellular processes","Biotin and Related Studies","Retinal Development and Disorders","Animals","Blotting, Western","Cerebrospinal Fluid","Chromatography, High Pressure Liquid","Dogs","Electrophoresis, Polyacrylamide Gel","Enzyme-Linked Immunosorbent Assay","Humans","Molecular Weight","Prealbumin","Retinol-Binding Proteins","Retinol-Binding Proteins, Plasma","Species Specificity","Vitamin A"],"mesh_terms":["Animals","Cerebrospinal Fluid","Chromatography, High Pressure Liquid","Dogs","Electrophoresis, Polyacrylamide Gel","Enzyme-Linked Immunosorbent Assay","Humans","Molecular Weight","Prealbumin","Retinol-Binding Proteins","Species Specificity","Vitamin A","Blotting, Western","Retinol-Binding Proteins, Plasma"],"keywords":["Transthyretin","Retinol binding protein","Cerebrospinal fluid","Retinol","Endocrinology","Internal medicine","Chemistry","Vitamin","Western blot","Molecular mass","Blood proteins","Biology","Biochemistry","Medicine","Gene","Enzyme"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T16:41:23.259531Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}