{"doi":"10.1016/j.trsl.2014.06.005","title":"Targeting RAS-MAPK-ERK and PI3K-AKT-mTOR signal transduction pathways to chemosensitize anaplastic thyroid carcinoma","abstract":null,"journal":"Translational Research","year":2014,"id":591431,"datarank":2.4838239151708654,"base_score":4.04305126783455,"endowment":4.04305126783455,"self_citation_contribution":0.6064576901751826,"citation_network_contribution":1.8773662249956826,"self_endowment_contribution":0.6064576901751826,"citer_contribution":1.8773662249956826,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":48,"citers_with_citation_signal":43,"citers_with_endowment":43,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1513244,"name":"Milica Pesic","orcid":null,"position":1,"is_corresponding":false},{"id":1513245,"name":"Tijana Stankovic","orcid":null,"position":2,"is_corresponding":false},{"id":1513246,"name":"Jelena Dinic","orcid":null,"position":3,"is_corresponding":false},{"id":1513247,"name":"Zorka Milovanovic","orcid":null,"position":4,"is_corresponding":false},{"id":1513248,"name":"Jelena Stojsic","orcid":null,"position":5,"is_corresponding":false},{"id":1513249,"name":"Radan Dzodic","orcid":null,"position":6,"is_corresponding":false},{"id":1513250,"name":"Nikola Tanic","orcid":null,"position":7,"is_corresponding":false},{"id":1513251,"name":"Jasna Bankovic","orcid":null,"position":8,"is_corresponding":false},{"id":1513243,"name":"Zorica Milosevic","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Targeting RAS-MAPK-ERK and PI3K-AKT-mTOR signal transduction pathways to chemosensitize anaplastic thyroid carcinoma","abstract":"Anaplastic thyroid carcinoma (ATC) is a rare, but aggressive and chemoresistant tumor with dismal prognosis. Most ATCs harbor mutations that activate RAS/MAPK/ERK and PI3K/AKT/mTOR pathways. Therefore, we investigated and correlated the expression of phosphatase and tensin homolog, pERK, and pAKT proteins as well as mutations of BRAF, RAS, and p53 genes in samples of patients with ATC. Furthermore, we evaluated the potential of inhibition of these pathways on chemosensitization of ATC using 2 thyroid carcinoma cell lines (FRO and SW1736). Our results revealed a negative correlation between the activity of RAS-MAPK-ERK and PI3K-AKT-mTOR pathways in samples of patients. To be specific, the PI3K-AKT-mTOR pathway was suppressed in patients with activated NRAS or high pERK expression. In vitro results suggest that the inhibition of either RAS-MAPK-ERK or PI3K-AKT-mTOR components may confer sensitivity of thyroid cancer cells to classic chemotherapeutics. This may form a basis for the development of novel genetic-based therapeutic approach for this cancer type.","is_dataset_classified":null,"base_score":4.04305126783455,"endowment":4.04305126783455,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25016932","pmcid":null,"openalex_id":"https://openalex.org/W2024936926","authors":[],"funders":[{"funder_name":"Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja","grant_id":"","title":null}],"total_grants":1,"fwci":3.1861,"citation_percentile":0.92038993,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":3},{"year":2016,"count":8},{"year":2017,"count":3},{"year":2018,"count":9},{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":8},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1931524414002126?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1931524414002126?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.trsl.2014.06.005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25016932","host_type":"repository"},{"url":"https://ibiss-r.rcub.bg.ac.rs/handle/123456789/2133","host_type":"repository"}],"fields_of_study":["Thyroid Cancer Diagnosis and Treatment","Cancer-related Molecular Pathways","PI3K/AKT/mTOR signaling in cancer","Aged","Aged, 80 and over","Alcohol Oxidoreductases","Antineoplastic Agents","Cell Line, Tumor","Drug Resistance, Neoplasm","Extracellular Signal-Regulated MAP Kinases","Female","Gene Expression Regulation, Neoplastic","Humans","Male","Middle Aged","PTEN Phosphohydrolase","Phosphatidylinositol 3-Kinases","Proto-Oncogene Proteins c-akt","Signal Transduction","TOR Serine-Threonine Kinases","Thyroid Carcinoma, Anaplastic","Thyroid Neoplasms","Tumor Suppressor Protein p53","ras Proteins"],"mesh_terms":["Aged","Aged, 80 and over","Alcohol Oxidoreductases","Antineoplastic Agents","Female","Humans","Male","Middle Aged","Thyroid Neoplasms","Signal Transduction","Gene Expression Regulation, Neoplastic","Tumor Suppressor Protein p53","ras Proteins","Drug Resistance, Neoplasm","Phosphatidylinositol 3-Kinases","Cell Line, Tumor","Extracellular Signal-Regulated MAP Kinases","Proto-Oncogene Proteins c-akt","PTEN Phosphohydrolase","TOR Serine-Threonine Kinases","Thyroid Carcinoma, Anaplastic"],"keywords":["PI3K/AKT/mTOR pathway","MAPK/ERK pathway","Cancer research","Protein kinase B","Signal transduction","Anaplastic thyroid cancer","Medicine","Thyroid","Biology","Internal medicine","Cell biology","Thyroid cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T16:35:55.173684Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}