{"doi":"10.1016/j.trecan.2023.02.002","title":"Targeting synthetic lethal paralogs in cancer","abstract":null,"journal":"Trends in Cancer","year":2023,"id":628622,"datarank":0.6141516843333151,"base_score":4.0943445622221,"endowment":4.0943445622221,"self_citation_contribution":0.6141516843333151,"citation_network_contribution":0.0,"self_endowment_contribution":0.6141516843333151,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":915724,"name":"Ishan Mehta","orcid":"0000-0002-2939-917X","position":1,"is_corresponding":false},{"id":1627638,"name":"Narod Kebabci","orcid":null,"position":2,"is_corresponding":false},{"id":13189,"name":"David J. Adams","orcid":"0000-0001-9490-0306","position":3,"is_corresponding":false},{"id":607901,"name":"Colm J. Ryan","orcid":"0000-0003-2750-9854","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Targeting synthetic lethal paralogs in cancer","abstract":"Synthetic lethal interactions, where mutation of one gene renders cells sensitive to inhibition of another gene, can be exploited for the development of targeted therapeutics in cancer. Pairs of duplicate genes (paralogs) often share common functionality and hence are a potentially rich source of synthetic lethal interactions. Because the majority of human genes have paralogs, exploiting such interactions could be a widely applicable approach for targeting gene loss in cancer. Moreover, existing small-molecule drugs may exploit synthetic lethal interactions by inhibiting multiple paralogs simultaneously. Consequently, the identification of synthetic lethal interactions between paralogs could be extremely informative for drug development. Here we review approaches to identify such interactions and discuss some of the challenges of exploiting them.","is_dataset_classified":null,"base_score":4.0943445622221,"endowment":4.0943445622221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36890003","pmcid":null,"openalex_id":"https://openalex.org/W4323311024","authors":[],"funders":[{"funder_name":"Science Foundation Ireland","grant_id":"18/CRT/6214","title":"SFI Centre for Research Training in Genomics Data Science"},{"funder_name":"Science Foundation Ireland","grant_id":"20/FFP-P/8641","title":"Understanding and predicting context-specific synthetic lethality in cancer"},{"funder_name":"EU Framework Programme for Research and Innovation Marie Skłodowska-Curie Actions","grant_id":"H2020-MSCA-COFUND-2019-945385","title":null},{"funder_name":"Medical Research Council","grant_id":"MR/V000292/1","title":null},{"funder_name":"Irish Research Council","grant_id":"unidentified","title":"unidentified"},{"funder_name":"European Commission","grant_id":"945385","title":"Doctorate School in Integrated Genomics Research"},{"funder_name":"Wellcome Trust","grant_id":"","title":null},{"funder_name":"Irish Research Council","grant_id":"","title":null},{"funder_name":"Horizon 2020","grant_id":"","title":null}],"total_grants":9,"fwci":5.6572,"citation_percentile":0.97332241,"influential_citations":0,"citation_trend":[{"year":2023,"count":8},{"year":2024,"count":30},{"year":2025,"count":15},{"year":2026,"count":6}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://www.cell.com/article/S2405803323000225/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S2405803323000225/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2405803323000225?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2405803323000225?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.trecan.2023.02.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36890003","host_type":"repository"}],"fields_of_study":["Protein Degradation and Inhibitors","CRISPR and Genetic Engineering","Ubiquitin and proteasome pathways","Humans","Neoplasms","Mutation"],"mesh_terms":["Humans","Mutation","Neoplasms"],"keywords":["Biology","Synthetic lethality","Computational biology","Gene","Lethal allele","Identification (biology)","Drug discovery","Cancer","Genetics","Bioinformatics","DNA repair","Target Identification","Paralogs","Crispr Screening","Neoplasms","Mutation","Humans"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T14:20:54.481160Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}