{"doi":"10.1016/j.transci.2009.03.016","title":"Plasma levels of FL and SDF-1 and expression of FLT-3 and CXCR4 on CD34+ cells assessed pre and post hematopoietic stem cell mobilization in patients with hematologic malignancies and in healthy donors","abstract":null,"journal":"Transfusion and Apheresis Science","year":2009,"id":603249,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1547487,"name":"Dulce Marta Schimieguel","orcid":null,"position":1,"is_corresponding":false},{"id":1547489,"name":"Eliza Yuriko Sugano Kimura","orcid":null,"position":2,"is_corresponding":false},{"id":200278,"name":"Mihoko Yamamoto","orcid":null,"position":3,"is_corresponding":false},{"id":1547491,"name":"José Salvador Rodrigues de Oliveira","orcid":null,"position":4,"is_corresponding":false},{"id":1547486,"name":"Karin Zattar Cecyn","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Plasma levels of FL and SDF-1 and expression of FLT-3 and CXCR4 on CD34+ cells assessed pre and post hematopoietic stem cell mobilization in patients with hematologic malignancies and in healthy donors","abstract":"Peripheral blood stem cells (PBSC) became the main source of cells for autologous transplantation. Alterations in the expression of adhesion molecules are essential in the CD34+ cells mobilization process. These molecules are involved in the interaction between hematopoietic and stromal cells and they have been disclosed as a considerable factor to the trafficking and homing of the CD34+ progenitor cells. This is a non-randomized PBSC mobilization study designed to evaluate the influence and behavior of FL and SDF-1 and their receptors in two different moments, prior and after HPCs mobilization, with the yield of CD34+ cells collected by apheresis. There was higher concentration of FL and lower of SDF-1 plasma level at post than pre PBSC mobilization (p=0.001 and p=0.012, respectively) regarding all individuals searched, but without any correlation with a good yield of CD34+ cells. However, CXCR4 expressions on the CD34+ cells from bone marrow aspirates (BMA), at pre and post mobilization showed a difference statistical significant for those individuals with good yield of CD34+ cells (p=0,036), but not achieved for poor yield (p=0,156). There was a higher expression of CXCR4 in steady-state for the successfully individuals than for those unsuccessfully (529.84+/-54.68 and 496.31+/-97.51, respectively). In conclusion, we confirmed the important role of CXCR4/SDF-1 axis in the process of PBSC mobilization.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19380254","pmcid":null,"openalex_id":"https://openalex.org/W2008204787","authors":[],"funders":[],"total_grants":0,"fwci":1.2711,"citation_percentile":0.79795674,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2014,"count":1},{"year":2019,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S147305020900069X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S147305020900069X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.transci.2009.03.016","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19380254","host_type":"repository"},{"url":"http://repositorio.unifesp.br/handle/11600/31579","host_type":"repository"}],"fields_of_study":["Hematopoietic Stem Cell Transplantation","Chemokine receptors and signaling","Immunotherapy and Immune Responses"],"mesh_terms":["Adult","Bone Marrow Examination","Female","Hematopoietic Stem Cells","Humans","Male","Middle Aged","Down-Regulation","Antigens, CD34","Hematopoietic Stem Cell Mobilization","Receptors, CXCR4","Peripheral Blood Stem Cell Transplantation","fms-Like Tyrosine Kinase 3","Chemokine CXCL12","Young Adult"],"keywords":["CD34","Homing (biology)","CXCR4","Plerixafor","Mobilization","Haematopoiesis","Stem cell","Stromal cell","Progenitor cell","Bone marrow","Apheresis","Medicine","Immunology","Cancer research","Andrology","Chemistry","Internal medicine","Cell biology","Biology","Receptor","Chemokine","Platelet"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T21:26:26.677862Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}