{"doi":"10.1016/j.tranon.2021.101084","title":"A clinical and molecular portrait of non-metastatic anal squamous cell carcinoma","abstract":"Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy associated with high-risk Human papillomavirus (HPV) infection. Despite improved outcomes in non-metastatic ASCC, definitive chemoradiotherapy constitutes the standard treatment for localized disease. Evidences for predictive and prognostic biomarkers are limited. Here, we performed a viral, immune, and mutational characterization of 79 non-metastatic ASCC patients with complete definitive chemoradiotherapy. HPV-16 was detected in 91% of positive cases in single infections (78%) or in coinfections with multiple genotypes (22%). Fifty-four percent of non-metastatic ASCC cases displayed mutations affecting cancer driver genes such as PIK3CA (21% of cases), TP53 (15%), FBXW7 (9%), and APC (6%). PD-L1 expression was detected in 57% of non-metastatic ASCC. Increased PD-L1 positive cases (67%) were detected in patients with complete response compared with non-complete response to treatment (37%) (p = 0.021). Furthermore, patients with PD-L1 positive tumors were significantly associated with better disease-free survival (DFS) and overall survival (OS) compared with patients with PD-L1 negative tumors (p = 0.006 and p = 0.002, respectively). PD-L1 expression strongly impacts CR rate and survival of non-metastatic ASCC patients after standard definitive chemoradiotherapy. PD-L1 expression could be used to stratify good versus poor responders avoiding the associated morbidity with abdominal perineal resection.","journal":"Translational Oncology","year":2021,"id":172406,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9323,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":708544,"name":"Mariano Golubicki","orcid":"0000-0002-3773-8581","position":1,"is_corresponding":false},{"id":708545,"name":"Juan Robbio","orcid":"0000-0002-3616-1709","position":2,"is_corresponding":false},{"id":709368,"name":"Gonzalo Ruiz","orcid":null,"position":3,"is_corresponding":false},{"id":709369,"name":"Florencia Guerra","orcid":null,"position":4,"is_corresponding":false},{"id":708546,"name":"Javier Mariani","orcid":"0000-0002-9372-6817","position":5,"is_corresponding":false},{"id":709370,"name":"Rubén Salanova","orcid":null,"position":6,"is_corresponding":false},{"id":708547,"name":"Ana Cabanne","orcid":"0000-0003-3567-8180","position":7,"is_corresponding":false},{"id":709371,"name":"Martín Eleta","orcid":null,"position":8,"is_corresponding":false},{"id":708548,"name":"Joaquín V. González","orcid":"0000-0002-3082-6503","position":9,"is_corresponding":false},{"id":708549,"name":"Jorge Basiletti","orcid":"0000-0002-7247-1413","position":10,"is_corresponding":false},{"id":708550,"name":"Marı́a Alejandra Picconi","orcid":"0000-0002-5930-9040","position":11,"is_corresponding":false},{"id":709372,"name":"Guillermo Masciángioli","orcid":null,"position":12,"is_corresponding":false},{"id":709373,"name":"Marcela Carballido","orcid":null,"position":13,"is_corresponding":false},{"id":708551,"name":"Enrique Roca","orcid":"0000-0003-4890-8969","position":14,"is_corresponding":false},{"id":708552,"name":"Guillermo Méndez","orcid":"0000-0003-4675-6498","position":15,"is_corresponding":false},{"id":708553,"name":"Mariana Coraglio","orcid":"0000-0002-0183-2218","position":16,"is_corresponding":false},{"id":375972,"name":"Martı́n C. Abba","orcid":"0000-0002-9206-2369","position":17,"is_corresponding":false},{"id":708543,"name":"Soledad Iseas","orcid":"0000-0002-5401-5094","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T23:46:41.424716Z","pmid":"33789221","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}