{"doi":"10.1016/j.trac.2020.115988","title":"Chemical derivatization in LC-MS-based metabolomics study","abstract":null,"journal":"TrAC Trends in Analytical Chemistry","year":2020,"id":645911,"datarank":0.7814229229262133,"base_score":5.209486152841421,"endowment":5.209486152841421,"self_citation_contribution":0.7814229229262133,"citation_network_contribution":0.0,"self_endowment_contribution":0.7814229229262133,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":182,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":975055,"name":"Liang Li","orcid":"0000-0002-9347-2108","position":1,"is_corresponding":false},{"id":1105022,"name":"Shuang Zhao","orcid":"0000-0002-1943-8542","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chemical derivatization in LC-MS-based metabolomics study","abstract":"Abstract   Because of great diversity of chemical and physical properties and wide ranges of concentrations of different metabolites in metabolome samples, metabolome analysis is a challenging task. Compromises in coverage, quantification accuracy and sample throughput are often used to provide a sufficient amount of metabolomic information for a biological or clinical application. Chemical derivatization of metabolites offers an opportunity to improve the overall analytical performance of liquid chromatography mass spectrometry (LC-MS)-based metabolomics. This review highlights recent progresses (since 2016) in the field of chemical derivatization LC-MS for both targeted and untargeted metabolome analysis. Due to increased recognition of the benefits of derivatization in LC-MS metabolome analysis, many research groups have been involved in advancing this active research field. Due to space limitation, we selected a few examples of recently reported derivatization methods and applications to showcase the advantages of chemical derivatization, compared to conventional label-free methods.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S016599362030217X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S016599362030217X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.trac.2020.115988","host_type":""},{"url":"https://dx.doi.org/10.1016/j.trac.2020.115988","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences","01 natural sciences","0104 chemical sciences"],"mesh_terms":[],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T10:38:13.023553Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}