{"doi":"10.1016/j.toxlet.2023.12.009","title":"The mechanism of blood coagulation induced by sodium dehydroacetate via the regulation of the mTOR/ERK pathway in rats","abstract":null,"journal":"Toxicology Letters","year":2024,"id":628712,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":276790,"name":"Qingqi Zhang","orcid":null,"position":1,"is_corresponding":false},{"id":1627905,"name":"Weiya Zhao","orcid":null,"position":2,"is_corresponding":false},{"id":618475,"name":"Xin Chen","orcid":"0000-0003-3885-4944","position":3,"is_corresponding":false},{"id":115690,"name":"Yumei Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":643256,"name":"Meng Zhang","orcid":"0000-0001-6422-2102","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The mechanism of blood coagulation induced by sodium dehydroacetate via the regulation of the mTOR/ERK pathway in rats","abstract":"Sodium dehydroacetate (DHA-S), a potent antifungal and antibacterial agent, is widely used in food, feed and cosmetics. However, recent studies have shown that DHA-S could pose a risk for human and animal health. We had previously reported that DHA-S could cause coagulation disorders in rats and chicken. In the present study, we further confirmed that DHA-S induced blood coagulation via VKORC1 and VKORC1L1 in rats, and elucidated the role played by mTOR/ERK signaling. The in vivo studies demonstrated that PT, APTT, and DHA-S content and relative protein expressions in tissues rebounded after drug withdrawal. In BRL-3A cells, 1.0 mM DHA-S increased the expression levels of mTOR, p-mTOR and p-ERK and decreased the levels of VKORC1, VKORC1L1 and Vitamin K. Rapamycin significantly decreased the expression levels of p-mTOR and p-ERK, while FR180204 (p-ERK Inhibition) lead to a decrease in p-ERK level. Rapamycin and FR180202 attenuated the inhibitory effect of DHA-S on VKORC1, VKORC1L1 and vitamin K levels. In addition, DHA-S increased the expression levels of mTOR, p-mTOR and p-ERK in male and female rat livers and prolonged PT and APTT. In summary, this study indicated that DHA-S induced blood coagulation via the modulation of the mTOR/ERK pathway in rats.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38103582","pmcid":null,"openalex_id":"https://openalex.org/W4389753022","authors":[],"funders":[{"funder_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","grant_id":"D18007","title":null}],"total_grants":1,"fwci":0.901,"citation_percentile":0.71388389,"influential_citations":0,"citation_trend":[{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0378427423011177?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0378427423011177?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.toxlet.2023.12.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38103582","host_type":"repository"}],"fields_of_study":["Vitamin K Research Studies","Eicosanoids and Hypertension Pharmacology","PI3K/AKT/mTOR signaling in cancer","Humans","Rats","Male","Female","Animals","MAP Kinase Signaling System","Vitamin K Epoxide Reductases","Blood Coagulation","Vitamin K","TOR Serine-Threonine Kinases","Sirolimus","Pyrones"],"mesh_terms":["Animals","Blood Coagulation","Female","Humans","Male","Pyrones","Vitamin K","Sirolimus","MAP Kinase Signaling System","Rats","TOR Serine-Threonine Kinases","Vitamin K Epoxide Reductases"],"keywords":["PI3K/AKT/mTOR pathway","MAPK/ERK pathway","Pharmacology","Chemistry","Internal medicine","Endocrinology","Medicine","Kinase","Biochemistry","Signal transduction","Blood coagulation","Vitamin K","Dehydroacetic Acid","Vitamin K Epoxide Reductase"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T14:44:53.954353Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}