{"doi":"10.1016/j.toxlet.2021.12.006","title":"Integration of data from the in vitro long-term exposure study on human endothelial cells and the in silico analysis: A case of dibutyl phthalate-induced vascular dysfunction","abstract":null,"journal":"Toxicology Letters","year":2022,"id":651933,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1700444,"name":"Dunja Kokai","orcid":"0000-0002-3876-7093","position":1,"is_corresponding":false},{"id":1700446,"name":"Biljana Tesic","orcid":null,"position":2,"is_corresponding":false},{"id":1700447,"name":"Svetlana Fa","orcid":"0000-0002-4009-9530","position":3,"is_corresponding":false},{"id":1700448,"name":"Dragana Samardzija Nenadov","orcid":"0000-0002-5100-2108","position":4,"is_corresponding":false},{"id":1700449,"name":"Kristina Pogrmic-Majkic","orcid":null,"position":5,"is_corresponding":false},{"id":1700452,"name":"Nebojsa Andric","orcid":"0000-0003-1025-8358","position":6,"is_corresponding":false},{"id":1700442,"name":"Bojana Stanic","orcid":"0000-0002-3049-4190","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Integration of data from the in vitro long-term exposure study on human endothelial cells and the in silico analysis: A case of dibutyl phthalate-induced vascular dysfunction","abstract":"General population is exposed to dibutyl phthalate (DBP) through continuous use of various consumer products. DBP exhibits its effects mainly on the endocrine and reproductive system but it can also affect the function of the vasculature; however, the underlying mechanisms behind DBP-induced vascular dysfunction are not fully understood. To infer pathways, molecular functions, biological processes, and human diseases associated with DBP exposure, we integrated the toxicogenomic data obtained from the 4-week-long exposure of human vascular endothelial cells (ECs) to three environmentally relevant concentrations of DBP with the in silico analysis. Nine genes were affected by DBP exposure: six of the integrin family, VCAM1, ICAM1, and MMP2. As shown by the in silico analysis, changes in DBP-affected genes could affect extracellular matrix and binding of molecules and cells to ECs, thereby altering cell adhesion and migration. Several pathways, molecular functions, and biological processes were further identified to provide insight into the DBP-vascular disease relationships and the potential mechanism of action. The top three human disease categories associated with DBP exposure and vascular dysfunction include cardiovascular, cerebrovascular, and immune system diseases. Integration of experimental and in silico approaches may offer better understanding of the potential human health risks associated with DBP exposure.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34902519","pmcid":null,"openalex_id":"https://openalex.org/W4200588922","authors":[],"funders":[{"funder_name":"Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja","grant_id":"451-03-9/2021-14/200125","title":null}],"total_grants":1,"fwci":1.0522,"citation_percentile":0.73186243,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":4},{"year":2024,"count":4},{"year":2025,"count":2},{"year":2026,"count":3}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0378427421009061?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0378427421009061?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.toxlet.2021.12.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34902519","host_type":"repository"}],"fields_of_study":["Effects and risks of endocrine disrupting chemicals","3D Printing in Biomedical Research","Pluripotent Stem Cells Research","Cell Adhesion","Cell Line","Cell Movement","Cell Survival","Computer Simulation","Dibutyl Phthalate","Drug Administration Schedule","Endothelial Cells","Gene Expression Regulation","Gene Regulatory Networks","Humans","Integrins","Models, Biological","RNA, Messenger","Signal Transduction"],"mesh_terms":["Cell Adhesion","Cell Line","Cell Movement","Cell Survival","Computer Simulation","Dibutyl Phthalate","Drug Administration Schedule","Gene Expression Regulation","Humans","Models, Biological","RNA, Messenger","Signal Transduction","Integrins","Endothelial Cells","Gene Regulatory Networks"],"keywords":["In silico","Dibutyl phthalate","Biology","Population","Cell biology","Phthalate","Extracellular matrix","Pharmacology","Gene","Chemistry","Genetics","Medicine","In vitro","Human Endothelial Cells","Vascular Dysfunction"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T11:15:49.580647Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}