{"doi":"10.1016/j.tox.2024.153873","title":"Inhibitory effects of parabens on human and rat 17β-hydroxysteroid dehydrogenase 1: Mechanisms of action and impact on hormone synthesis","abstract":null,"journal":"Toxicology","year":2024,"id":652862,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1703263,"name":"Chaochao Gong","orcid":null,"position":1,"is_corresponding":false},{"id":1635753,"name":"Yunbing Tang","orcid":null,"position":2,"is_corresponding":false},{"id":1207293,"name":"Yang Zhu","orcid":"0000-0002-7384-607X","position":3,"is_corresponding":false},{"id":516513,"name":"Shaowei Wang","orcid":"0000-0002-1267-9554","position":4,"is_corresponding":false},{"id":1703264,"name":"Ren-shan Ge","orcid":null,"position":5,"is_corresponding":false},{"id":1703265,"name":"Yingfen Ying","orcid":null,"position":6,"is_corresponding":false},{"id":1703262,"name":"Zouqi Chen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Inhibitory effects of parabens on human and rat 17β-hydroxysteroid dehydrogenase 1: Mechanisms of action and impact on hormone synthesis","abstract":"Parabens are commonly used preservatives in cosmetics, food, and pharmaceutical products. The objective of this study was to examine the effect of nine parabens on human and rat 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1) in human placental and rat ovarian cytosols, as well as on estradiol synthesis in BeWo cells. The results showed that the IC<sub>50</sub> values for these compounds varied from methylparaben with the weakest inhibition (106.42 μM) to hexylparaben with the strongest inhibition (2.05 μM) on human 17β-HSD1. Mode action analysis revealed that these compounds acted as mixed inhibitors. For rats, the IC<sub>50</sub> values ranged from the weakest inhibition for methylparaben (no inhibition at 100 μM) to the most potent inhibition for hexylparaben (0.87 μM), and they functioned as mixed inhibitors. Docking analysis indicated that parabens bind to the region bridging the NADPH and steroid binding sites of human 17β-HSD1 and the NADPH binding site of rat 17β-HSD1. Bivariate correlation analysis demonstrated negative correlations between LogP, molecular weight, heavy atoms, and apolar desolvation energy, and the IC<sub>50</sub> values of these compounds. In conclusion, this study identified the inhibitory effects of parabens and their binding mechanisms on human and rat 17β-HSD1, as well as their impact on hormone synthesis.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38986729","pmcid":null,"openalex_id":"https://openalex.org/W4400478156","authors":[],"funders":[{"funder_name":"Zhejiang Province Natural Science Foundation","grant_id":"LY22H040010","title":null},{"funder_name":"NSFC","grant_id":"82371610","title":null},{"funder_name":"NSFC","grant_id":"82301892","title":null}],"total_grants":3,"fwci":2.1109,"citation_percentile":0.88807291,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0300483X24001549?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0300483X24001549?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tox.2024.153873","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38986729","host_type":"repository"}],"fields_of_study":["Hormonal Regulation and Hypertension","Apelin-related biomedical research","Estrogen and related hormone effects","Parabens","Animals","Humans","Rats","Female","Molecular Docking Simulation","Estradiol","Placenta","17-Hydroxysteroid Dehydrogenases","Pregnancy","Preservatives, Pharmaceutical","Ovary","Cell Line, Tumor","Enzyme Inhibitors","Binding Sites","Estradiol Dehydrogenases"],"mesh_terms":["Animals","Binding Sites","Enzyme Inhibitors","Estradiol","Estradiol Dehydrogenases","Female","Humans","Ovary","Parabens","Placenta","Pregnancy","Preservatives, Pharmaceutical","17-Hydroxysteroid Dehydrogenases","Cell Line, Tumor","Rats","Molecular Docking Simulation"],"keywords":["Chemistry","Hormone","Dehydrogenase","Hydroxysteroid dehydrogenase","Action (physics)","Pharmacology","Inhibitory postsynaptic potential","Endocrinology","Internal medicine","Biochemistry","Enzyme","Biology","Medicine","Physics","Estradiol","Parabens","Docking Analysis","17Β-hsd1","Bivariate Correlation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T17:17:39.728609Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}