{"doi":"10.1016/j.tjnut.2023.03.026","title":"Association between Fat-Free Mass Loss, Changes in Appetite, and Weight Regain in Individuals with Obesity","abstract":null,"journal":"The Journal of Nutrition","year":2023,"id":675525,"datarank":0.5097927936122199,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.12505038999298929,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.12505038999298929,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":12,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1765016,"name":"Siren Nymo","orcid":null,"position":1,"is_corresponding":false},{"id":1765018,"name":"Silvia R. Coutinho","orcid":null,"position":2,"is_corresponding":false},{"id":953023,"name":"Jens F. Rehfeld","orcid":"0000-0002-4718-9571","position":3,"is_corresponding":false},{"id":321519,"name":"Gary R. Hunter","orcid":"0000-0002-5015-242X","position":4,"is_corresponding":false},{"id":321518,"name":"Barbara A. Gower","orcid":"0000-0001-8461-4613","position":5,"is_corresponding":false},{"id":1765015,"name":"Catia Martins","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Association between Fat-Free Mass Loss, Changes in Appetite, and Weight Regain in Individuals with Obesity","abstract":"BACKGROUND: The role of fat-free mass loss (FFML) in modulating weight regain in individuals with obesity, as well as the potential mechanisms involved, remain inconsistent. OBJECTIVES: The aim of this study was to determine if % FFML following weight loss (WL) is a predictor of weight regain and to investigate the association between %FFML and changes in appetite markers. METHODS: ; age: 44 ± 9 y; 29 males) underwent 8 wk of a very low energy diet (550-660 kcal/d), followed by 4 wk of gradual refeeding and weight stabilization and a 9-mo maintenance program (eucaloric diet). The primary outcomes were body weight and body composition (fat mass and fat-free mass). The secondary outcomes were plasma concentrations of β-hydroxybutyrate (a marker of ketosis) in fasting and appetite-related hormones (ghrelin, glucagon-like peptide 1, peptide YY, and cholecystokinin) and subjective appetite feelings during fasting and every 30 min after a fixed breakfast for 2.5 h. All were measured at baseline, week 9, and 1 y [week 13 in 35 subjects (25 males)]. The association between FFML, weight regain, and changes in appetite was assessed by linear regression. RESULTS: WL at week 9 was 17.5 ± 4.3kg and %FFML 20.4 ± 10.6%. Weight regain at 1 y was 1.7 ± 8.2 kg (8.8 ± 45.0%). After adjusting for WL and fat mass at baseline, %FFML at week 9 was not a significant predictor of weight regain. Similar results were seen at week 13. The greater the %FFML at week 9, but not 13, the smaller the reduction, or greater the increase in basal ghrelin concentration (β: -3.2; 95% CI: -5.0, -1.1; P = 0.003), even after adjusting for WL and β-hydroxybutyrate. CONCLUSIONS: %FFML was not a significant predictor of weight regain at 1 y in individuals with obesity. However, a greater %FFML was accompanied by a greater increase in ghrelin secretion under ketogenic conditions, suggesting a link between fat-free mass and appetite regulation. This trial was registered at clinicaltrials.gov as NCT01834859.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36963504","pmcid":null,"openalex_id":"https://openalex.org/W4360620261","authors":[],"funders":[],"total_grants":0,"fwci":1.4156,"citation_percentile":0.78179098,"influential_citations":0,"citation_trend":[{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":6},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.tjnut.2023.03.026","host_type":"journal"},{"url":"https://doi.org/10.1016/j.tjnut.2023.03.026","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022316623354993?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022316623354993?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36963504","host_type":"repository"},{"url":"https://hdl.handle.net/11250/3115672","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/8748191d-0e5e-421a-94f6-2d08c924f67f","host_type":"repository"},{"url":"http://hdl.handle.net/10852/107199","host_type":"repository"}],"fields_of_study":["Regulation of Appetite and Obesity","Diet and metabolism studies","Bariatric Surgery and Outcomes","Male","Humans","Adult","Middle Aged","Appetite","Ghrelin","3-Hydroxybutyric Acid","Obesity","Weight Loss","Peptide YY","Weight Gain"],"mesh_terms":["Adult","Appetite","Humans","Male","Middle Aged","Obesity","Weight Gain","Weight Loss","Peptide YY","3-Hydroxybutyric Acid","Ghrelin"],"keywords":["Appetite","Obesity","Fat free mass","Weight loss","Body mass index","Medicine","Endocrinology","Fat mass","Internal medicine","Body weight","Hunger","Ghrelin","Weight Regain","Fat-free Mass"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T01:09:31.673214Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}