{"doi":"10.1016/j.tjnut.2023.03.015","title":"Long-Term Association Between Maternal Preconception Hemoglobin Concentration, Anemia, and Child Health and Development in Vietnam","abstract":"BACKGROUND: The long-term association between preconception maternal hemoglobin (Hb) concentrations and child health and development is unclear. OBJECTIVES: We examined associations between maternal preconception Hb concentrations and anemia with 1) birth outcomes (weight, length, preterm, gestational age, small for gestational age); 2) child Hb at 3 mo, 6 mo, 12 mo, and 24 mo; and 3) motor and mental development at 12 mo and 24 mo (Bayley scales for infant development) and cognitive functioning at 6-7 y (Wechsler Intelligence Scale for Children). METHODS: We used data from a randomized controlled trial (PRECONCEPT) conducted in Vietnam. Over 5000 women who were intending to conceive were recruited, and offspring were prospectively followed from birth (n = 1599) through 6-7 y (n = 1318). Multivariable linear and logistic regressions were used to assess the association between preconception Hb or anemia (Hb < 12g/dL) on child health and development outcomes, adjusted by supplementation group (tested for interactions) and confounding at maternal, child, and household levels. RESULTS: At preconception enrollment, 20% of the women were anemic. Maternal preconception Hb was positively associated with child Hb at 3 mo (0.06; 95% CI: 0.01, 0.12), 6 mo (0.08; 95% CI: 0.03, 0.13), 12 mo (0.10; 95% CI: 0.04, 0.15), and 24 mo (0.07; 95% CI: 0.02, 0.12). Likewise, maternal preconception Hb was associated with reduced risk of child anemia at 6 mo (0.89; 95% CI: 0.81, 0.98), 12 mo (0.81; 95% CI: 0.74, 0.89), and 24 mo (0.87; 95% CI: 0.79, 0.95). Maternal preconception anemia was negatively associated with cognition (-1.64; 95% CI: -3.09, -0.19) and language development (-1.61; 95% CI: -3.20, -0.03) at 24 mo. Preconception Hb was not associated with birth outcomes or cognitive outcomes at 6-7 y. CONCLUSIONS: Maternal preconception Hb was associated with child Hb across the first 1000 d of life. However, preconception Hb was not a significant predictor of birth outcomes or cognitive outcomes at 6-7 y in this cohort from Vietnam. CLINICAL TRIAL REGISTRATION: PRECONCEPT study (NCT: 01665378).","journal":"Journal of Nutrition","year":2023,"id":342411,"datarank":0.6395610298801726,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.23335349971484098,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.23335349971484098,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":10,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9252,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01665378"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1078922,"name":"Phuong Hong Nguyen","orcid":"0000-0003-3418-1674","position":1,"is_corresponding":false},{"id":1078923,"name":"Lan Mai Tran","orcid":"0000-0001-5129-5716","position":2,"is_corresponding":false},{"id":1078924,"name":"Khương Quỳnh Long","orcid":"0000-0002-1232-6230","position":3,"is_corresponding":false},{"id":38911,"name":"Reynaldo Martorell","orcid":"0000-0001-8862-7243","position":4,"is_corresponding":false},{"id":371409,"name":"Usha Ramakrishnan","orcid":"0000-0003-1694-1238","position":5,"is_corresponding":false},{"id":371410,"name":"Melissa Young","orcid":"0000-0002-2768-1673","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T01:11:12.506815Z","pmid":"36925072","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}