{"doi":"10.1016/j.tins.2005.12.005","title":"Microglial phenotype: is the commitment reversible?","abstract":null,"journal":"Trends in Neurosciences","year":2006,"id":606494,"datarank":0.9099162135155623,"base_score":6.066108090103747,"endowment":6.066108090103747,"self_citation_contribution":0.9099162135155623,"citation_network_contribution":0.0,"self_endowment_contribution":0.9099162135155623,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":430,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":7843,"name":"Oleg Butovsky","orcid":"0000-0003-0186-8867","position":1,"is_corresponding":false},{"id":387819,"name":"Wolfgang Brück","orcid":"0000-0002-6881-4479","position":2,"is_corresponding":false},{"id":1521041,"name":"Uwe-Karsten Hanisch","orcid":null,"position":3,"is_corresponding":false},{"id":74394,"name":"Michal Schwartz","orcid":"0000-0003-4015-7507","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Microglial phenotype: is the commitment reversible?","abstract":"Microglia, the standby cells for immune defense in the CNS, have a reputation for exacerbating the neural damage that occurs in neurodegenerative diseases. However, research over the past few years has established that microglia do not constitute a single, uniform cell population, but rather comprise a family of cells with diverse phenotypes--some that are beneficial and others that the CNS can barely tolerate and that are therefore destructive. This finding raised several questions. What instructs microglia to acquire a particular phenotype, and how do these phenotypes differ? How committed are microglia to a specific phenotype? Can destructive microglia become protective, and can protective microglia retain their beneficial phenotype even when they encounter a destructive environment? Here, we address these questions, and the background of research that elicited them.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16406093","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0166223605003231?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0166223605003231?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Microglia","Animals","Humans","Inflammation","Phenotype"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T04:40:16.146246Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}