{"doi":"10.1016/j.tim.2019.08.007","title":"Species-Specific Host–Virus Interactions: Implications for Viral Host Range and Virulence","abstract":null,"journal":"Trends in Microbiology","year":2020,"id":592321,"datarank":3.2833176988329544,"base_score":4.990432586778736,"endowment":4.990432586778736,"self_citation_contribution":0.7485648880168105,"citation_network_contribution":2.534752810816144,"self_endowment_contribution":0.7485648880168105,"citer_contribution":2.534752810816144,"corpus_percentile":null,"corpus_rank":null,"citation_count":146,"citer_count":129,"citers_with_citation_signal":92,"citers_with_endowment":92,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":445015,"name":"Greg Brennan","orcid":"0000-0002-4339-9045","position":1,"is_corresponding":false},{"id":445017,"name":"Stefan Rothenburg","orcid":"0000-0002-2525-8230","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Species-Specific Host–Virus Interactions: Implications for Viral Host Range and Virulence","abstract":"A growing number of studies indicate that host species-specific and virus strain-specific interactions of viral molecules with the host innate immune system play a pivotal role in determining virus host range and virulence. Because interacting proteins are likely constrained in their evolution, mutations that are selected to improve virus replication in one species may, by chance, alter the ability of a viral antagonist to inhibit immune responses in hosts the virus has not yet encountered. Based on recent findings of host-species interactions of poxvirus, herpesvirus, and influenza virus proteins, we propose a model for viral fitness and host range which considers the full interactome between a specific host species and a virus, resulting from the combination of all interactions, positive and negative, that influence whether a virus can productively infect a cell and cause disease in different hosts.","is_dataset_classified":null,"base_score":4.990432586778736,"endowment":4.990432586778736,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31597598","pmcid":"PMC6925338","openalex_id":"https://openalex.org/W2978726586","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI114851","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI135257","title":null},{"funder_name":"National Institute of Allergy and Infectious Diseases","grant_id":"","title":null}],"total_grants":3,"fwci":8.2138,"citation_percentile":0.98303909,"influential_citations":0,"citation_trend":[{"year":2020,"count":13},{"year":2021,"count":17},{"year":2022,"count":26},{"year":2023,"count":24},{"year":2024,"count":30},{"year":2025,"count":21},{"year":2026,"count":15}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6925338","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6925338","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0966842X19302203?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0966842X19302203?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tim.2019.08.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31597598","host_type":"repository"},{"url":"https://escholarship.org/uc/item/6z7142b9","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6925338","host_type":"repository"}],"fields_of_study":["Influenza Virus Research Studies","HIV Research and Treatment","interferon and immune responses","Animals","DNA Viruses","Evolution, Molecular","Host Specificity","Host-Pathogen Interactions","Humans","Influenza, Human","Viral Nonstructural Proteins","Viral Proteins","Virulence","Virus Replication"],"mesh_terms":["Animals","DNA Viruses","Humans","Influenza, Human","Viral Proteins","Virulence","Virus Replication","Viral Nonstructural Proteins","Evolution, Molecular","Host-Pathogen Interactions","Host Specificity"],"keywords":["Biology","Virus","Host (biology)","Viral replication","Viral evolution","Virulence","Virology","Interactome","Viral entry","Innate immune system","Permissive","Immune system","Genetics","Gene","Genome","Poxvirus","Pkr","Host–pathogen Interactions","Herpesvirus, Influenza Virus","Viral Fitness Interactome"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T13:10:42.534270Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}