{"doi":"10.1016/j.tig.2025.04.007","title":"Selection on the epigenome: small RNA inheritance in animal evolution","abstract":null,"journal":"Trends in Genetics","year":2025,"id":653360,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":165554,"name":"Simone Immler","orcid":"0000-0003-1234-935X","position":1,"is_corresponding":false},{"id":1704748,"name":"Tracey Chapman","orcid":null,"position":2,"is_corresponding":false},{"id":1197381,"name":"Alexei A. Maklakov","orcid":"0000-0002-5809-1203","position":3,"is_corresponding":false},{"id":1704745,"name":"Isaac Harris","orcid":"0009-0008-1460-6579","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Selection on the epigenome: small RNA inheritance in animal evolution","abstract":"The inheritance of small RNAs (sRNAs) is taxonomically widespread. Changing environments alter the production and presence of sRNAs in the germline, and this can in theory either increase offspring phenotypic variance as an evolutionary bet-hedging strategy or elicit predictive and adaptive phenotypic responses that increase offspring fitness. Nevertheless, the putative role of sRNA inheritance systems in adaptive evolution is still debated and it is currently unclear how selection acts on sRNAs. We outline two adaptive sRNA inheritance strategies - specialist and generalist - and discuss non-adaptive alternatives and the evolutionary implications of different strategies. Our review suggests that the role of natural selection in sRNA inheritance has been significantly overlooked, potentially leading to misinterpretations of the causal agents and the evolutionary implications of sRNA inheritance.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40379494","pmcid":null,"openalex_id":"https://openalex.org/W4410390308","authors":[],"funders":[{"funder_name":"Leverhulme Trust","grant_id":"RPG-2023-068","title":null}],"total_grants":1,"fwci":1.6252,"citation_percentile":0.82546749,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.cell.com/action/showPdf?pii=S0168952525000824","host_type":"journal"},{"url":"https://www.cell.com/action/showPdf?pii=S0168952525000824","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168952525000824?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168952525000824?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tig.2025.04.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40379494","host_type":"repository"},{"url":"https://ueaeprints.uea.ac.uk/id/eprint/99284/","host_type":"repository"}],"fields_of_study":["CRISPR and Genetic Engineering","Chromosomal and Genetic Variations","RNA and protein synthesis mechanisms"],"mesh_terms":["Epigenome","Animals","Biological Evolution","Selection, Genetic","Evolution, Molecular","Inheritance Patterns","Epigenesis, Genetic","RNA, Small Untranslated"],"keywords":["Biology","Epigenome","Selection (genetic algorithm)","Evolutionary biology","Inheritance (genetic algorithm)","Genetics","Computational biology","DNA methylation","Gene","Gene expression","Evolution","Natural selection","Epigenetics","Small Rnas","Transgenerational Epigenetic Inheritance"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T21:07:22.612040Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}