{"doi":"10.1016/j.tig.2024.02.006","title":"PCNA cycling dynamics during DNA replication and repair in mammals","abstract":null,"journal":"Trends in Genetics","year":2024,"id":653868,"datarank":0.7244336055361993,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"self_citation_contribution":0.5289540786924243,"citation_network_contribution":0.19547952684377504,"self_endowment_contribution":0.5289540786924243,"citer_contribution":0.19547952684377504,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":30,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1313644,"name":"Juyeong Yoo","orcid":null,"position":1,"is_corresponding":false},{"id":411227,"name":"Kyungjae Myung","orcid":"0000-0001-7975-6190","position":2,"is_corresponding":false},{"id":411226,"name":"Sukhyun Kang","orcid":"0000-0002-7567-0231","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"PCNA cycling dynamics during DNA replication and repair in mammals","abstract":"Proliferating cell nuclear antigen (PCNA) is a eukaryotic replicative DNA clamp. Furthermore, DNA-loaded PCNA functions as a molecular hub during DNA replication and repair. PCNA forms a closed homotrimeric ring that encircles the DNA, and association and dissociation of PCNA from DNA are mediated by clamp-loader complexes. PCNA must be actively released from DNA after completion of its function. If it is not released, abnormal accumulation of PCNA on chromatin will interfere with DNA metabolism. ATAD5 containing replication factor C-like complex (RLC) is a PCNA-unloading clamp-loader complex. ATAD5 deficiency causes various DNA replication and repair problems, leading to genome instability. Here, we review recent progress regarding the understanding of the action mechanisms of PCNA unloading complex in DNA replication/repair pathways.","is_dataset_classified":null,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38485608","pmcid":null,"openalex_id":"https://openalex.org/W4392744150","authors":[],"funders":[{"funder_name":"Institute for Basic Science","grant_id":"","title":null}],"total_grants":1,"fwci":5.0339,"citation_percentile":0.96515853,"influential_citations":0,"citation_trend":[{"year":2024,"count":4},{"year":2025,"count":13},{"year":2026,"count":14}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0168952524000428?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168952524000428?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tig.2024.02.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38485608","host_type":"repository"}],"fields_of_study":["DNA Repair Mechanisms","Carcinogens and Genotoxicity Assessment","PARP inhibition in cancer therapy"],"mesh_terms":["ATPases Associated with Diverse Cellular Activities","Animals","Chromatin","DNA","DNA Repair","DNA Replication","DNA-Binding Proteins","Humans","Mammals","Proliferating Cell Nuclear Antigen","Genomic Instability"],"keywords":["Biology","Proliferating cell nuclear antigen","DNA replication","Replication (statistics)","DNA repair","Genetics","DNA","Cell biology","Computational biology","Evolutionary biology","Virology","PCNA","Rfc","Atad5"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T01:38:42.739255Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}