{"doi":"10.1016/j.tig.2008.06.001","title":"Revealing the architecture of gene regulation: the promise of eQTL studies","abstract":null,"journal":"Trends in Genetics","year":2008,"id":639611,"datarank":12.783053145790856,"base_score":6.373319789577012,"endowment":6.373319789577012,"self_citation_contribution":0.9559979684365519,"citation_network_contribution":11.827055177354303,"self_endowment_contribution":0.9559979684365519,"citer_contribution":11.827055177354303,"corpus_percentile":null,"corpus_rank":null,"citation_count":585,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":272268,"name":"Scott A. Rifkin","orcid":"0000-0001-8476-3256","position":1,"is_corresponding":false},{"id":5156,"name":"Jonathan K. Pritchard","orcid":"0000-0002-8828-5236","position":2,"is_corresponding":false},{"id":65310,"name":"Yoav Gilad","orcid":"0000-0001-8284-8926","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Revealing the architecture of gene regulation: the promise of eQTL studies","abstract":"Expression quantitative trait loci (eQTL) mapping studies have become a widely used tool for identifying genetic variants that affect gene regulation. In these studies, expression levels are viewed as quantitative traits, and gene expression phenotypes are mapped to particular genomic loci by combining studies of variation in gene expression patterns with genome-wide genotyping. Results from recent eQTL mapping studies have revealed substantial heritable variation in gene expression within and between populations. In many cases, genetic factors that influence gene expression levels can be mapped to proximal (putatively cis) eQTLs and, less often, to distal (putatively trans) eQTLs. Beyond providing great insight into the biology of gene regulation, a combination of eQTL studies with results from traditional linkage or association studies of human disease may help predict a specific regulatory role for polymorphic sites previously associated with disease.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18597885","pmcid":"PMC2583071","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"F32 GM080966","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM077959","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"5F32GM080966","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"HG002772","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM077959","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"R01 HG002772","title":null}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2583071","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0168952508001777?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168952508001777?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Animals","Humans","Chromosome Mapping","Genetic Complementation Test","Gene Expression Regulation","Phenotype","Quantitative Trait Loci","Models, Genetic"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refsnp"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T01:01:40.319668Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}