{"doi":"10.1016/j.tibtech.2018.07.003","title":"Modular Metabolic Engineering for Biobased Chemical Production","abstract":null,"journal":"Trends in Biotechnology","year":2019,"id":687406,"datarank":0.7289718606542509,"base_score":4.859812404361672,"endowment":4.859812404361672,"self_citation_contribution":0.7289718606542509,"citation_network_contribution":0.0,"self_endowment_contribution":0.7289718606542509,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":128,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1795796,"name":"Juan C. Villada","orcid":null,"position":1,"is_corresponding":false},{"id":617778,"name":"Patrick K. H. Lee","orcid":"0000-0003-0911-5317","position":2,"is_corresponding":false},{"id":1261260,"name":"Hongyuan Lu","orcid":"0009-0006-0824-1134","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Modular Metabolic Engineering for Biobased Chemical Production","abstract":"Microorganisms can manufacture a wide range of biobased chemicals that are useful for diverse industrial applications. However, the overexpression of heterologous enzymes in recombinant strains often leads to metabolic imbalance, resulting in growth retardation and suboptimal production of the target compounds. Here we discuss the recent development of modular metabolic engineering approaches that enable the global fine-tuning of engineered pathways by modularizing the synthetic pathway in single or multiple hosts. In particular, we highlight applications with microbial consortia. To build a vibrant biobased economy, multivariate modular metabolic engineering (MMME), modular coculture engineering (MCE), and spatiotemporal and integrative genome-scale metabolic modeling can be exploited to expedite strain optimization and improve the production of a broad variety of high-value biobased chemicals.","is_dataset_classified":null,"base_score":4.859812404361672,"endowment":4.859812404361672,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30064888","pmcid":null,"openalex_id":"https://openalex.org/W2884755188","authors":[],"funders":[],"total_grants":0,"fwci":4.2067,"citation_percentile":0.95548647,"influential_citations":0,"citation_trend":[{"year":2019,"count":14},{"year":2020,"count":18},{"year":2021,"count":19},{"year":2022,"count":30},{"year":2023,"count":11},{"year":2024,"count":12},{"year":2025,"count":15},{"year":2026,"count":9}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S016777991830194X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S016777991830194X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tibtech.2018.07.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30064888","host_type":"repository"}],"fields_of_study":["Microbial Metabolic Engineering and Bioproduction","Plant biochemistry and biosynthesis","Viral Infectious Diseases and Gene Expression in Insects","Metabolic Engineering","Metabolic Networks and Pathways","Metabolism","Microbial Consortia","Organic Chemicals"],"mesh_terms":["Metabolism","Organic Chemicals","Metabolic Networks and Pathways","Microbial Consortia","Metabolic Engineering"],"keywords":["Metabolic engineering","Modular design","Synthetic biology","Biochemical engineering","Heterologous","Biotechnology","Computer science","Computational biology","Protein engineering","Production (economics)","Industrial biotechnology","Metabolic pathway","Biology","Enzyme","Biochemistry","Engineering","Coculture","Genome-scale Metabolic Model","Biobased Chemicals","Modular Engineering"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Industry, innovation and infrastructure"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.15001333.v1","title":"Additional file 1 of Bacterial alginate metabolism: an important pathway for bioconversion of brown algae","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.15001333","title":"Additional file 1 of Bacterial alginate metabolism: an important pathway for bioconversion of brown algae","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19351014.v1","title":"Additional file 1 of Engineering microbial consortia of Elizabethkingia meningoseptica and Escherichia coli strains for the biosynthesis of vitamin K2","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19351014","title":"Additional file 1 of Engineering microbial consortia of Elizabethkingia meningoseptica and Escherichia coli strains for the biosynthesis of vitamin K2","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T21:55:45.262214Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}