{"doi":"10.1016/j.tibs.2023.11.006","title":"TRAPs: the ‘elevator-with-an-operator’ mechanism","abstract":null,"journal":"Trends in Biochemical Sciences","year":2024,"id":682306,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":763080,"name":"Michael Currie","orcid":"0000-0003-1509-7581","position":1,"is_corresponding":false},{"id":421865,"name":"Renwick C. J. Dobson","orcid":"0000-0002-5506-4939","position":2,"is_corresponding":false},{"id":421864,"name":"Christopher R. Horne","orcid":"0000-0003-1318-514X","position":3,"is_corresponding":false},{"id":437680,"name":"Rachel A. North","orcid":"0000-0001-5011-1567","position":4,"is_corresponding":false},{"id":1782521,"name":"James S. Davies","orcid":"0000-0003-4029-1650","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"TRAPs: the ‘elevator-with-an-operator’ mechanism","abstract":"Tripartite ATP-independent periplasmic (TRAP) transporters are nutrient-uptake systems found in bacteria and archaea. These evolutionary divergent transporter systems couple a substrate-binding protein (SBP) to an elevator-type secondary transporter, which is a first-of-its-kind mechanism of transport. Here, we highlight breakthrough TRAP transporter structures and recent functional data that probe the mechanism of transport. Furthermore, we discuss recent structural and biophysical studies of the ion transporter superfamily (ITS) members and highlight mechanistic principles that are relevant for further exploration of the TRAP transporter system.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38102017","pmcid":null,"openalex_id":"https://openalex.org/W4389743630","authors":[],"funders":[{"funder_name":"Royal Society Te Apārangi","grant_id":"UOC1506","title":null},{"funder_name":"Marsden Fund","grant_id":"","title":null},{"funder_name":"University of Canterbury","grant_id":"","title":null},{"funder_name":"Canterbury Medical Research Foundation","grant_id":"","title":null},{"funder_name":"Australian Institute of Nuclear Science and Engineering","grant_id":"","title":null},{"funder_name":"Biomolecular Interaction Centre, University of Canterbury","grant_id":"","title":null}],"total_grants":6,"fwci":1.7359,"citation_percentile":0.86133228,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"bronze","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"http://www.cell.com/article/S0968000423002955/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S0968000423002955/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0968000423002955?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0968000423002955?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tibs.2023.11.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38102017","host_type":"repository"}],"fields_of_study":["Bacterial Genetics and Biotechnology","RNA and protein synthesis mechanisms","Enzyme Structure and Function","Bacterial Proteins","Membrane Transport Proteins","Carrier Proteins","Bacteria","Biological Transport"],"mesh_terms":["Bacteria","Bacterial Proteins","Biological Transport","Carrier Proteins","Membrane Transport Proteins"],"keywords":["Transporter","Periplasmic space","Mechanism (biology)","Archaea","Transport protein","Membrane transport protein","Biology","Biophysics","Chemistry","Biochemistry","Computational biology","Gene","Physics","Escherichia coli","Sialic acid","membrane proteins","Transport Mechanism","Secondary Transporters","Ion Transporter Superfamily","Tripartite Atp-independent Periplasmic (Trap) Transporters"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T20:02:05.790387Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}