{"doi":"10.1016/j.tibs.2016.02.003","title":"Intermediates of Metabolism: From Bystanders to Signalling Molecules","abstract":null,"journal":"Trends in Biochemical Sciences","year":2016,"id":686861,"datarank":0.7924805593106984,"base_score":5.2832037287379885,"endowment":5.2832037287379885,"self_citation_contribution":0.7924805593106984,"citation_network_contribution":0.0,"self_endowment_contribution":0.7924805593106984,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":196,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":10,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1794383,"name":"Danilo Cucchi","orcid":null,"position":1,"is_corresponding":false},{"id":773530,"name":"Joanne Smith","orcid":"0000-0001-9578-8520","position":2,"is_corresponding":false},{"id":932731,"name":"Valentina Pucino","orcid":"0000-0002-7683-4568","position":3,"is_corresponding":false},{"id":1794385,"name":"Claire Elizabeth Macdougall","orcid":null,"position":4,"is_corresponding":false},{"id":932734,"name":"Claudio Mauro","orcid":"0000-0002-3736-0099","position":5,"is_corresponding":false},{"id":1794382,"name":"Robert Haas","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Intermediates of Metabolism: From Bystanders to Signalling Molecules","abstract":"The integration of biochemistry into immune cell biology has contributed immensely to our understanding of immune cell function and the associated pathologies. So far, most studies have focused on the regulation of metabolic pathways during an immune response and their contribution to its success. More recently, novel signalling functions of metabolic intermediates are being discovered that might play important roles in the regulation of immunity. Here we describe the three long-known small metabolites lactate, acetyl-CoA, and succinate in the context of immunometabolic signalling. Functions of these ubiquitous molecules are largely dependent on their intra- and extracellular concentrations as well as their subcompartmental localisation. Importantly, the signalling functions of these metabolic intermediates extend beyond self-regulatory roles and include cell-to-cell communication and sensing of microenvironmental conditions to elicit stress responses and cellular adaptation.","is_dataset_classified":null,"base_score":5.2832037287379885,"endowment":5.2832037287379885,"datacite_reuse_total":10,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26935843","pmcid":null,"openalex_id":"https://openalex.org/W2283191725","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"1263270","title":null},{"funder_name":"British Heart Foundation","grant_id":"FS/12/38/29640","title":null},{"funder_name":"Medical Research 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Reticulum Stress and Disease","Cancer, Hypoxia, and Metabolism","interferon and immune responses"],"mesh_terms":["Acetyl Coenzyme A","Cell Communication","Citric Acid Cycle","Fatty Acids","Glycolysis","Humans","Immunity, Innate","Macrophages","Neurons","T-Lymphocytes","Signal Transduction","Cytokines","Lactic Acid","Succinic Acid","Endothelial Cells"],"keywords":["Signalling","Immune system","Biology","Cell biology","Cell signaling","Context (archaeology)","Cell metabolism","Function (biology)","Cellular adaptation","Metabolic pathway","Extracellular","Cell function","Metabolism","Adaptation (eye)","Signal transduction","Cellular metabolism","Cell","Biochemistry","Neuroscience","Immunology","Gene","Lactate","Tricarboxylic acid cycle","glycolysis","Succinate","Fatty Acid Oxidation"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.26608527.v1","title":"Additional file 3 of Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like 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