{"doi":"10.1016/j.tibs.2015.01.002","title":"UPR, autophagy, and mitochondria crosstalk underlies the ER stress response","abstract":null,"journal":"Trends in Biochemical Sciences","year":2015,"id":685706,"datarank":1.0551581894873256,"base_score":7.034387929915503,"endowment":7.034387929915503,"self_citation_contribution":1.0551581894873256,"citation_network_contribution":0.0,"self_endowment_contribution":1.0551581894873256,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1134,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":25,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":146661,"name":"Ze’ev A. Ronai","orcid":null,"position":1,"is_corresponding":false},{"id":1791478,"name":"Daniela Senft","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"UPR, autophagy, and mitochondria crosstalk underlies the ER stress response","abstract":"Cellular stress, induced by external or internal cues, activates several well-orchestrated processes aimed at either restoring cellular homeostasis or committing to cell death. Those processes include the unfolded protein response (UPR), autophagy, hypoxia, and mitochondrial function, which are part of the global endoplasmic reticulum (ER) stress (ERS) response. When one of the ERS elements is impaired, as often occurs under pathological conditions, overall cellular homeostasis may be perturbed. Further, activation of the UPR could trigger changes in mitochondrial function or autophagy, which could modulate the UPR, exemplifying crosstalk processes. Among the numerous factors that control the magnitude or duration of these processes are ubiquitin ligases, which govern overall cellular stress outcomes. Here we summarize crosstalk among the fundamental processes governing ERS responses.","is_dataset_classified":null,"base_score":7.034387929915503,"endowment":7.034387929915503,"datacite_reuse_total":25,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25656104","pmcid":"PMC4340752","openalex_id":"https://openalex.org/W2019263782","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA128814","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P01 CA128814","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA030199","title":null}],"total_grants":3,"fwci":31.4876,"citation_percentile":0.99921787,"influential_citations":0,"citation_trend":[{"year":2015,"count":18},{"year":2016,"count":60},{"year":2017,"count":69},{"year":2018,"count":70},{"year":2019,"count":94},{"year":2020,"count":110},{"year":2021,"count":109},{"year":2022,"count":132},{"year":2023,"count":159},{"year":2024,"count":125},{"year":2025,"count":117},{"year":2026,"count":71}],"oa_status":"bronze","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"http://www.cell.com/article/S0968000415000031/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S0968000415000031/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0968000415000031?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0968000415000031?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tibs.2015.01.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25656104","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4340752","host_type":"repository"}],"fields_of_study":["Endoplasmic Reticulum Stress and Disease","Autophagy in Disease and Therapy","Sirtuins and Resveratrol in Medicine","Animals","Autophagy","Cell Physiological Phenomena","Endoplasmic Reticulum Stress","Humans","Mitochondria","Stress, Physiological","Unfolded Protein Response"],"mesh_terms":["Animals","Autophagy","Cell Physiological Phenomena","Humans","Mitochondria","Stress, Physiological","Unfolded Protein Response","Endoplasmic Reticulum Stress"],"keywords":["Autophagy","Crosstalk","Mitochondrion","Unfolded protein response","Cell biology","Fight-or-flight response","Biology","Cellular stress response","Endoplasmic reticulum","Apoptosis","Genetics","Engineering","Gene","Electronic engineering","Mitochondria","Hypoxia","Ubiquitin","ER stress","Upr"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.12135078.v1","title":"Additional file 1 of PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia 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