{"doi":"10.1016/j.tetlet.2025.155778","title":"Bioinspired synthesis of a lactam analogue of abyssomicin C","abstract":"The bioinspired approach to abyssomicin C developed by Sorensen has been utilized to prepare a novel analog containing an α, β-unsaturated lactam. This synthesis was designed to utilize the intramolecular Diels-Alder reaction in late-stage synthesis to provide analogs that contain deep-seated modifications to explore their antimicrobial properties. Overall, installing this non-natural lactam moiety was successful and allowed for antimicrobial assessment of the analog, but the low yields highlight the frequent challenges of leveraging a bioinspired approach for a new-to-nature molecular target.","journal":"Tetrahedron Letters","year":2025,"id":571766,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9446,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":765887,"name":"Joshua G. Pierce","orcid":"0000-0001-9194-3765","position":1,"is_corresponding":false},{"id":1141419,"name":"Alex C. Edwards","orcid":"0000-0001-8608-0133","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:57:19.669553Z","pmid":"42232068","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}