{"doi":"10.1016/j.tet.2017.11.011","title":"Norbornene probes for the study of cysteine oxidation","abstract":null,"journal":"Tetrahedron","year":2018,"id":679854,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1776329,"name":"Kyle D. Farrell","orcid":null,"position":1,"is_corresponding":false},{"id":1776331,"name":"Mawey T. Akol","orcid":null,"position":2,"is_corresponding":false},{"id":1379531,"name":"Gregory H. Jones","orcid":"0000-0003-3275-1661","position":3,"is_corresponding":false},{"id":1776333,"name":"Matthew M. Tierney","orcid":null,"position":4,"is_corresponding":false},{"id":1776334,"name":"Holger B. Kramer","orcid":null,"position":5,"is_corresponding":false},{"id":1044979,"name":"Tara L. Pukala","orcid":"0000-0001-7391-1436","position":6,"is_corresponding":false},{"id":1776335,"name":"Gonçalo J.L. Bernardes","orcid":null,"position":7,"is_corresponding":false},{"id":1776336,"name":"Michael V. Perkins","orcid":null,"position":8,"is_corresponding":false},{"id":1774725,"name":"Justin M. Chalker","orcid":null,"position":9,"is_corresponding":false},{"id":1776326,"name":"Lisa J. Alcock","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Norbornene probes for the study of cysteine oxidation","abstract":"Cysteine residues on proteins can react with cellular oxidants such as hydrogen peroxide. While this process is important for scavenging excess reactive oxygen species, the products of this oxidation may also mediate cell signalling. To understand the role of cysteine oxidation in biology, selective probes are required to detect and quantify its occurrence. Cysteine oxidation products such as sulfenic acids are sometimes unstable and therefore short-lived. If such cysteine derivatives are to be analysed, rapid reaction with the probe is required. Here we introduce norbornene derivatives as probes for cysteine oxidation, and demonstrate their ability to trap sulfenic acids. The synthesis of norbornene derivatives containing alkyne or biotin affinity tags are also reported to facilitate the use of these probes in chemical biology and proteomics.","is_dataset_classified":null,"base_score":3.713572066704308,"endowment":3.713572066704308,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W2766540212","authors":[],"funders":[{"funder_name":"Australian Research Council","grant_id":"DE150101863","title":"Discovery Early Career Researcher Award - Grant ID: DE150101863"}],"total_grants":1,"fwci":1.9352,"citation_percentile":0.85678153,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":11},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":7},{"year":2023,"count":5},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S004040201731147X/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S004040201731147X/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S004040201731147X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S004040201731147X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tet.2017.11.011","host_type":"journal"},{"url":"https://authors.library.caltech.edu/82974/","host_type":"repository"},{"url":"http://hdl.handle.net/2440/111580","host_type":"repository"},{"url":"http://hdl.handle.net/2328/37890","host_type":"repository"},{"url":"http://publications.eng.cam.ac.uk/946075/","host_type":"repository"},{"url":"https://www.repository.cam.ac.uk/handle/1810/276800","host_type":"repository"},{"url":"https://doi.org/10.17863/cam.24087","host_type":"repository"},{"url":"https://dx.doi.org/10.17863/cam.24087","host_type":""},{"url":"https://dx.doi.org/10.1016/j.tet.2017.11.011","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.tet.2017.11.011","host_type":""}],"fields_of_study":["Click Chemistry and Applications","Biotin and Related Studies","Chemical Synthesis and Analysis"],"mesh_terms":[],"keywords":["Sulfenic acid","Chemistry","Cysteine","Norbornene","Hydrogen peroxide","Chemical biology","Combinatorial chemistry","Biotin","Amino acid","Biochemistry","Organic chemistry","Polymerization","Enzyme","34 Chemical Sciences","1.1 Normal biological development and functioning","3405 Organic Chemistry","540","Cysteine sulfenic acid","530","Oxidative stress"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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