{"doi":"10.1016/j.tem.2009.02.002","title":"Role of central melanocortin pathways in energy homeostasis","abstract":null,"journal":"Trends in Endocrinology & Metabolism","year":2009,"id":646847,"datarank":0.7346759699926367,"base_score":4.897839799950911,"endowment":4.897839799950911,"self_citation_contribution":0.7346759699926367,"citation_network_contribution":0.0,"self_endowment_contribution":0.7346759699926367,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":133,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":542808,"name":"Daniel D. 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The central melanocortin system represents a crucial point of convergence for these signals and, thus, has a fundamental role in regulating body weight. The melanocortin ligands, synthesized in discrete neuronal populations within the hypothalamus and brainstem, modulate downstream homeostatic signalling via their action at central melanocortin-3 and -4 receptors. Intimately involved in both ingestive behaviour and energy expenditure, the melanocortin system has garnered much interest as a potential therapeutic target for human obesity.","is_dataset_classified":null,"base_score":4.897839799950911,"endowment":4.897839799950911,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19541496","pmcid":null,"openalex_id":"https://openalex.org/W1990119407","authors":[],"funders":[],"total_grants":0,"fwci":4.931,"citation_percentile":0.96404666,"influential_citations":0,"citation_trend":[{"year":2012,"count":12},{"year":2013,"count":9},{"year":2014,"count":11},{"year":2015,"count":5},{"year":2016,"count":7},{"year":2017,"count":12},{"year":2018,"count":5},{"year":2019,"count":6},{"year":2020,"count":10},{"year":2021,"count":7},{"year":2022,"count":4},{"year":2023,"count":4},{"year":2024,"count":4},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1043276009000551?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1043276009000551?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tem.2009.02.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19541496","host_type":"repository"}],"fields_of_study":["Regulation of Appetite and Obesity","Biochemical Analysis and Sensing Techniques","melanin and skin pigmentation"],"mesh_terms":["Energy Intake","Energy Metabolism","Humans","Signal Transduction","Melanocortins"],"keywords":["Melanocortin","Energy homeostasis","Melanocortin 4 receptor","Neuroscience","Homeostasis","Brainstem","Biology","Hypothalamus","Central nervous system","Melanocortin receptor","Glucose homeostasis","Melanocortins","Receptor","Endocrinology","Internal medicine","Obesity","Medicine","Insulin resistance","Hormone","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T15:19:42.634373Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}