{"doi":"10.1016/j.tcb.2025.01.004","title":"HELLS: the transcriptional sentinel","abstract":null,"journal":"Trends in Cell Biology","year":2025,"id":629554,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1564319,"name":"Giulia Gambarelli","orcid":null,"position":1,"is_corresponding":false},{"id":1414571,"name":"Alessia Ciarrocchi","orcid":"0000-0002-5541-2075","position":2,"is_corresponding":false},{"id":1564328,"name":"Valentina Fragliasso","orcid":"0000-0002-4189-0316","position":3,"is_corresponding":false},{"id":1564316,"name":"Selene Mallia","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"HELLS: the transcriptional sentinel","abstract":"The role of the chromatin remodeler HELicase Lymphoid Specific (HELLS) has been historically associated with DNA methylation and DNA damage repair. However, recent studies have shed light on an unexpected, multimodal, and direct participation of HELLS in transcriptional regulation. This forum article aims to discuss how, through different and context-specific mechanisms, HELLS modulates the expression of functionally related genes favoring transcriptional plasticity and phenotypic adaptation, ultimately safeguarding the genome organization and stability.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39890476","pmcid":null,"openalex_id":"https://openalex.org/W4406971009","authors":[],"funders":[{"funder_name":"Ministry of Health","grant_id":"","title":null},{"funder_name":"Fondazione AIRC per la ricerca sul cancro ETS","grant_id":"","title":null}],"total_grants":2,"fwci":2.4339,"citation_percentile":0.87605731,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":4}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.1016/j.tcb.2025.01.004","host_type":"journal"},{"url":"https://doi.org/10.1016/j.tcb.2025.01.004","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0962892425000042?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0962892425000042?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39890476","host_type":"repository"},{"url":"https://hdl.handle.net/11380/1384989","host_type":"repository"}],"fields_of_study":["Genomics and Chromatin Dynamics","RNA modifications and cancer","Epigenetics and DNA Methylation"],"mesh_terms":["Animals","DNA Helicases","Gene Expression Regulation","Humans","Transcription, Genetic","DNA Methylation","Chromatin Assembly and Disassembly"],"keywords":["Biology","Computational biology","Transcription","transcriptional factors","R-loop","Genome Integrity","Chromatin Remodeler"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T19:01:06.198903Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}