{"doi":"10.1016/j.tcb.2024.10.009","title":"Metabolism and mRNA translation: a nexus of cancer plasticity","abstract":null,"journal":"Trends in Cell Biology","year":2025,"id":612725,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1577773,"name":"Kaixiu Li","orcid":null,"position":1,"is_corresponding":false},{"id":1248114,"name":"Yuqing Wang","orcid":"0000-0002-0130-3965","position":2,"is_corresponding":false},{"id":1577774,"name":"Stéphane Rocchi","orcid":null,"position":3,"is_corresponding":false},{"id":124478,"name":"Shensi Shen","orcid":null,"position":4,"is_corresponding":false},{"id":1577775,"name":"Michael Cerezo","orcid":"0000-0002-3687-2009","position":5,"is_corresponding":false},{"id":1577772,"name":"Xinpu Tang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Metabolism and mRNA translation: a nexus of cancer plasticity","abstract":"Tumors often face energy deprivation due to mutations, hypoxia, and nutritional deficiencies within the harsh tumor microenvironment (TME), and as an effect of anticancer treatments. This metabolic stress triggers adaptive reprogramming of mRNA translation, which in turn adjusts metabolic plasticity and associated signaling pathways to ensure tumor cell survival. Emerging evidence is beginning to reveal the complex interplay between metabolism and mRNA translation, shedding light on the mechanisms that synchronize ribosome assembly and reconfigure translation programs under metabolic stress. This review explores recent advances in our understanding of the coordination between metabolism and mRNA translation, offering insights that could inform therapeutic strategies targeting both cancer metabolism and translation, with the aim of disrupting cancer cell plasticity and survival.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39603916","pmcid":null,"openalex_id":"https://openalex.org/W4404778663","authors":[],"funders":[{"funder_name":"Agence Nationale de la Recherche","grant_id":"ANR-23-CE14-0023 TRANSMET","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82473387","title":null},{"funder_name":"Sichuan University West China Hospital","grant_id":"Y2022JC002","title":null},{"funder_name":"Sichuan University","grant_id":"","title":null},{"funder_name":"Austrian Science Fund FWF","grant_id":"","title":null},{"funder_name":"KWF Kankerbestrijding","grant_id":"","title":null},{"funder_name":"Institut National de la Santé et de la Recherche Médicale","grant_id":"","title":null},{"funder_name":"Foundation for Medical Research","grant_id":"","title":null},{"funder_name":"Stichting Tegen Kanker","grant_id":"","title":null}],"total_grants":9,"fwci":1.33,"citation_percentile":0.80441398,"influential_citations":0,"citation_trend":[{"year":2025,"count":4},{"year":2026,"count":4}],"oa_status":"closed","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0962892424002253?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0962892424002253?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.tcb.2024.10.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39603916","host_type":"repository"}],"fields_of_study":["Metabolism, Diabetes, and Cancer","Cancer, Hypoxia, and Metabolism","RNA modifications and cancer"],"mesh_terms":["Cell Plasticity","Animals","Humans","Neoplasms","RNA, Messenger","Protein Biosynthesis","Signal Transduction","Tumor Microenvironment"],"keywords":["Biology","Translation (biology)","Nexus (standard)","Messenger RNA","Computational biology","Cell biology","Evolutionary biology","Genetics","Gene","Tumor Metabolism","Mrna Translation","Cancer Cell Plasticity"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T04:41:53.464438Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}