{"doi":"10.1016/j.surg.2022.09.025","title":"Clinical significance of immunocytochemical staining for peritoneal lavage cytology in pancreatic cancer","abstract":null,"journal":"Surgery","year":2022,"id":640455,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1664501,"name":"Katsuhisa Ohgi","orcid":"0000-0003-1647-1117","position":1,"is_corresponding":false},{"id":626435,"name":"Nobuyuki Ohike","orcid":"0000-0001-8631-821X","position":2,"is_corresponding":false},{"id":1664502,"name":"Kiyoshi Tone","orcid":null,"position":3,"is_corresponding":false},{"id":1664503,"name":"Tomoko Norose","orcid":null,"position":4,"is_corresponding":false},{"id":1664504,"name":"Teiichi Sugiura","orcid":null,"position":5,"is_corresponding":false},{"id":1664505,"name":"Ryo Ashida","orcid":null,"position":6,"is_corresponding":false},{"id":1664506,"name":"Mihoko Yamada","orcid":null,"position":7,"is_corresponding":false},{"id":1664507,"name":"Shimpei Otsuka","orcid":null,"position":8,"is_corresponding":false},{"id":1664508,"name":"Katsuhiko Uesaka","orcid":"0000-0002-9983-1730","position":9,"is_corresponding":false},{"id":1664500,"name":"Hidemasa Kubo","orcid":"0000-0002-7294-5148","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical significance of immunocytochemical staining for peritoneal lavage cytology in pancreatic cancer","abstract":"<h4>Background</h4>Peritoneal lavage cytology for pancreatic ductal adenocarcinoma is conducted with both an intraoperative rapid diagnosis by Papanicolaou staining (cytology-rapid) and a final diagnosis by immunocytochemical staining at a later date (cytology-final) in our hospital. However, the clinical significance of cytology-final has not yet been elucidated.<h4>Methods</h4>A total of 675 pancreatic ductal adenocarcinoma patients who underwent pancreatectomy and cytology between 2002 and 2018 were retrospectively reviewed. Diagnostic results of cytology-rapid and cytology-final and survival outcomes were analyzed.<h4>Results</h4>A total of 43 patients (6.4%) were diagnosed as cytology-rapid (+), and all of them were ultimately diagnosed as cytology-final (+). Among the 632 patients with cytology-rapid (-), 19 (3.0%) were eventually diagnosed as cytology-final (+). The overall survival of patients with cytology-rapid (+) and that of patients with cytology-rapid (-) did not differ to a statistically significant extent (median survival time 26.4 vs 32.9 months; P = .106). In contrast, the overall survival of patients who were diagnosed as a false-negative result by cytology-rapid was significantly worse than that of patients diagnosed as a true negative (18.7 vs 34.8 months; P = .031). The overall survival of patients with cytology-final (+) was significantly worse than that of patients with cytology-final (-) (23.6 vs 34.8 months; P = .012). A multivariate analysis showed that cytology-final (+) was an independent prognostic factor for the OS (hazard ratio = 1.43; P = .049), whereas cytology-rapid (+) was not.<h4>Conclusion</h4>Immunocytochemical staining may be a useful complement to a diagnosis of cytology by conventional Papanicolaou staining in pancreatic ductal adenocarcinoma patients.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36371356","pmcid":null,"openalex_id":"https://openalex.org/W4308645677","authors":[],"funders":[],"total_grants":0,"fwci":0.651,"citation_percentile":0.69583029,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":3}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0039606022007991?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0039606022007991?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.surg.2022.09.025","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36371356","host_type":"repository"}],"fields_of_study":["Pancreatic and Hepatic Oncology Research","Intraperitoneal and Appendiceal Malignancies","Pancreatitis Pathology and Treatment","Humans","Peritoneal Lavage","Retrospective Studies","Pancreatic Neoplasms","Carcinoma, Pancreatic Ductal","Staining and Labeling","Prognosis"],"mesh_terms":["Humans","Pancreatic Neoplasms","Peritoneal Lavage","Prognosis","Retrospective Studies","Staining and Labeling","Carcinoma, Pancreatic Ductal"],"keywords":["Cytology","Medicine","Papanicolaou stain","Adenocarcinoma","Internal medicine","Pathology","Gastroenterology","Cancer","Cervical cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T11:58:34.594874Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}