{"doi":"10.1016/j.surg.2020.11.015","title":"Portal vein resection during pancreaticoduodenectomy for pancreatic neuroendocrine tumors. An international multicenter comparative study","abstract":null,"journal":"Surgery","year":2021,"id":625264,"datarank":0.5101796072493234,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.0,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1616784,"name":"Domenico Tamburrino","orcid":"0000-0003-1435-3651","position":1,"is_corresponding":false},{"id":1616785,"name":"Stefano Partelli","orcid":"0000-0001-8938-6170","position":2,"is_corresponding":false},{"id":1616786,"name":"Panagis Lykoudis","orcid":"0000-0003-2170-0471","position":3,"is_corresponding":false},{"id":1616787,"name":"Peter Pipan","orcid":null,"position":4,"is_corresponding":false},{"id":1616788,"name":"Francesca Di Salvo","orcid":null,"position":5,"is_corresponding":false},{"id":1616789,"name":"Nassiba Beghdadi","orcid":null,"position":6,"is_corresponding":false},{"id":1281375,"name":"Safi Dokmak","orcid":"0000-0002-3335-4388","position":7,"is_corresponding":false},{"id":1616790,"name":"Dominik Wiese","orcid":null,"position":8,"is_corresponding":false},{"id":627903,"name":"Luca Landoni","orcid":"0000-0002-2474-3496","position":9,"is_corresponding":false},{"id":1616791,"name":"Chiara Nessi","orcid":"0000-0002-0470-1440","position":10,"is_corresponding":false},{"id":1616792,"name":"O.R.C. Busch","orcid":null,"position":11,"is_corresponding":false},{"id":1616793,"name":"Niccolò Napoli","orcid":null,"position":12,"is_corresponding":false},{"id":1616794,"name":"Jin-Young Jang","orcid":null,"position":13,"is_corresponding":false},{"id":380165,"name":"Wooil Kwon","orcid":"0000-0002-4827-7805","position":14,"is_corresponding":false},{"id":10994,"name":"Marco Del Chiaro","orcid":"0000-0002-7400-013X","position":15,"is_corresponding":false},{"id":1616795,"name":"Chiara Scandavini","orcid":"0000-0002-8287-6764","position":16,"is_corresponding":false},{"id":1616796,"name":"Mahmoud Abu-Awwad","orcid":null,"position":17,"is_corresponding":false},{"id":1320805,"name":"Thomas Armstrong","orcid":"0000-0002-9153-8070","position":18,"is_corresponding":false},{"id":1616797,"name":"Mohamed Abu Hilal","orcid":null,"position":19,"is_corresponding":false},{"id":22947,"name":"Peter J. Allen","orcid":null,"position":20,"is_corresponding":false},{"id":1616798,"name":"Ammar Javed","orcid":null,"position":21,"is_corresponding":false},{"id":1616799,"name":"Magnus Kjellman","orcid":null,"position":22,"is_corresponding":false},{"id":1018396,"name":"Alain Sauvanet","orcid":"0000-0002-7436-5999","position":23,"is_corresponding":false},{"id":205283,"name":"Detlef K. Bartsch","orcid":null,"position":24,"is_corresponding":false},{"id":13240,"name":"Claudio Bassi","orcid":"0000-0002-5416-329X","position":25,"is_corresponding":false},{"id":1616800,"name":"E.J.M. Nieveen van Dijkum","orcid":"0000-0002-3029-6071","position":26,"is_corresponding":false},{"id":1616801,"name":"M.G. Besselink","orcid":null,"position":27,"is_corresponding":false},{"id":1018369,"name":"Ugo Boggi","orcid":"0000-0002-7505-5896","position":28,"is_corresponding":false},{"id":1616802,"name":"Sun-Whe Kim","orcid":null,"position":29,"is_corresponding":false},{"id":635001,"name":"Jin He","orcid":"0000-0002-5108-4182","position":30,"is_corresponding":false},{"id":1616803,"name":"Christofer L. Wolfgang","orcid":null,"position":31,"is_corresponding":false},{"id":1018392,"name":"Massimo Falconi","orcid":"0000-0001-9654-7243","position":32,"is_corresponding":false},{"id":1616783,"name":"Giuseppe K. Fusai","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Portal vein resection during pancreaticoduodenectomy for pancreatic neuroendocrine tumors. An international multicenter comparative study","abstract":"BACKGROUND: The role of portal vein resection for pancreatic cancer is well established but not for pancreatic neuroendocrine neoplasms. Evidence from studies providing information on long-term outcome after venous resection in pancreatic neuroendocrine neoplasms patients is lacking.\nMETHODS: This is a multicenter retrospective cohort study comparing pancreaticoduodenectomy with vein resection with standard pancreaticoduodenectomy in patients with pancreatic neuroendocrine neoplasms. The primary endpoint was to evaluate the long-term survival in both groups. Progression-free survival and overall survival were calculated using the method of Kaplan and Meier, but a propensity score-matched cohort analysis was subsequently performed to remove selection bias and improve homogeneity. The secondary outcome was Clavien-Dindo ≥3.\nRESULTS: Sixty-one (11%) patients underwent pancreaticoduodenectomy with vein resection and 480 patients pancreaticoduodenectomy. Five (1%) perioperative deaths were recorded in the pancreaticoduodenectomy group, and postoperative clinically relevant morbidity rates were similar in the 2 groups (pancreaticoduodenectomy with vein resection 48% vs pancreaticoduodenectomy 33%). In the initial survival analysis, pancreaticoduodenectomy with vein resection was associated with worse 3-year progression-free survival (48% pancreaticoduodenectomy with vein resection vs 83% pancreaticoduodenectomy; P < .01) and 5-year overall survival (67% pancreaticoduodenectomy with vein resection vs 91% pancreaticoduodenectomy). After propensity score matching, no significant difference was found in both 3-year progression-free survival (49% pancreaticoduodenectomy with vein resection vs 59% pancreaticoduodenectomy; P = .14) and 5-year overall survival (71% pancreaticoduodenectomy with vein resection vs 69% pancreaticoduodenectomy; P = .98).\nCONCLUSION: This study demonstrates no significant difference in perioperative risk with a similar overall survival between pancreaticoduodenectomy and pancreaticoduodenectomy with vein resection. Tumor involvement of the superior mesenteric/portal vein axis should not preclude surgical resection in patients with locally advanced pancreatic neuroendocrine neoplasms.","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33357999","pmcid":null,"openalex_id":"https://openalex.org/W3115963476","authors":[],"funders":[],"total_grants":0,"fwci":2.1415,"citation_percentile":0.87421434,"influential_citations":0,"citation_trend":[{"year":2021,"count":2},{"year":2022,"count":4},{"year":2023,"count":5},{"year":2024,"count":4},{"year":2025,"count":10},{"year":2026,"count":4}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://discovery.ucl.ac.uk/10166388/2/Lykoudis_Portal%20vein%20resection%20during%20pancreaticoduodenectomy%20for%20pancreatic%20neuroendocrine%20tumors_AAM.pdf","host_type":"repository"},{"url":"https://discovery.ucl.ac.uk/10166388/2/Lykoudis_Portal%20vein%20resection%20during%20pancreaticoduodenectomy%20for%20pancreatic%20neuroendocrine%20tumors_AAM.pdf","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S003960602030800X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S003960602030800X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://discovery.ucl.ac.uk/id/eprint/10166388/","host_type":"repository"},{"url":"https://doi.org/10.1016/j.surg.2020.11.015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33357999","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/en/publications/778d675b-7af5-46e7-b9d1-a97d07246b31","host_type":"repository"},{"url":"https://research.vumc.nl/en/publications/ffc25ccf-4a03-4b23-b7d9-db8de665672c","host_type":"repository"},{"url":"https://pure.amc.nl/en/publications/portal-vein-resection-during-pancreaticoduodenectomy-for-pancreatic-neuroendocrine-tumors-an-international-multicenter-comparative-study(b5ecaa02-451f-4556-ae1f-22f44e6254c2).html","host_type":"repository"},{"url":"https://hdl.handle.net/11568/1068027","host_type":"repository"}],"fields_of_study":["Neuroendocrine Tumor Research Advances","Pancreatic and Hepatic Oncology Research","Lung Cancer Research Studies","Adult","Aged","Aged, 80 and over","Female","Humans","Male","Middle Aged","Neuroendocrine Tumors","Pancreatic Neoplasms","Pancreaticoduodenectomy","Portal Vein","Retrospective Studies","Young Adult"],"mesh_terms":["Adult","Aged","Aged, 80 and over","Female","Humans","Male","Middle Aged","Pancreatic Neoplasms","Portal Vein","Retrospective Studies","Pancreaticoduodenectomy","Neuroendocrine Tumors","Young Adult"],"keywords":["Pancreaticoduodenectomy","Medicine","Perioperative","Pancreatic cancer","Surgery","Clinical endpoint","Propensity score matching","Neuroendocrine tumors","Superior mesenteric vein","Retrospective cohort study","Survival rate","Gastroenterology","Internal medicine","Portal vein","Cancer","Resection","Randomized controlled trial"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T06:17:27.941122Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}