{"doi":"10.1016/j.surg.2017.01.019","title":"Diagnostic value of chromogranin A in pancreatic neuroendocrine tumors depends on tumor size: A prospective observational study from a single institute","abstract":null,"journal":"Surgery","year":2017,"id":652954,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":845236,"name":"Song Cheol Kim","orcid":null,"position":1,"is_corresponding":false},{"id":709991,"name":"Ki Byung Song","orcid":"0000-0001-5422-5481","position":2,"is_corresponding":false},{"id":1703574,"name":"Dae Wook Hwang","orcid":null,"position":3,"is_corresponding":false},{"id":646839,"name":"Jae Hoon Lee","orcid":"0000-0002-6170-8729","position":4,"is_corresponding":false},{"id":1703576,"name":"Sang Hyun Shin","orcid":null,"position":5,"is_corresponding":false},{"id":1703579,"name":"Seung Mo Hong","orcid":null,"position":6,"is_corresponding":false},{"id":1703581,"name":"Kwang-Min Park","orcid":null,"position":7,"is_corresponding":false},{"id":1703583,"name":"Young-Joo Lee","orcid":null,"position":8,"is_corresponding":false},{"id":845233,"name":"Eunsung Jun","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Diagnostic value of chromogranin A in pancreatic neuroendocrine tumors depends on tumor size: A prospective observational study from a single institute","abstract":"<h4>Background</h4>Chromogranin A has recently been recommended as the most practical tumor marker in patients with pancreatic neuroendocrine tumors. However, the diagnostic effectiveness of circulating chromogranin A levels remains controversial. Here, we aimed to assess the clinical diagnostic value of plasma chromogranin A levels for pancreatic neuroendocrine tumors.<h4>Methods</h4>Between June 2012 and June 2015, 110 consecutive patients with a suspected pancreatic neuroendocrine tumor were prospectively enrolled. We evaluated the diagnostic value of the chromogranin A assay for differentiating pancreatic neuroendocrine tumors from other tumors. The plasma chromogranin A levels in the pancreatic neuroendocrine tumor patients were examined according to various clinicopathologic factors.<h4>Results</h4>A total of 65 patients were diagnosed as having pancreatic neuroendocrine tumors, whereas 45 had other tumors. The median chromogranin A level in pancreatic neuroendocrine tumor cases was higher than that in cases of other tumors (pancreatic neuroendocrine tumors: 126.62 ng/mL, other tumors: 69.82 ng/mL). The sensitivity, specificity, and accuracy of the chromogranin A assay for pancreatic neuroendocrine tumor diagnosis were 49.2%, 77.8%, and 60.9%, respectively. The chromogranin A levels after operative resection were reduced or were confirmed as being within the normal range (78.9%) in most cases. Moreover, the chromogranin A level in pancreatic neuroendocrine tumors cases was correlated with tumor size based on comparisons with other tumors in the pancreas (P = .038). The sensitivity, specificity, and accuracy of the chromogranin A assay for large tumors were greater, at 64.3%, 100.0%, and 81.5%, respectively.<h4>Conclusion</h4>In clinical settings, the identification of pancreatic neuroendocrine tumors is vital for the development of therapeutic strategies. In large pancreatic tumors, the measurement of chromogranin A levels is very useful for distinguishing pancreatic neuroendocrine tumors from other tumors in the pancreas.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28262254","pmcid":null,"openalex_id":"https://openalex.org/W2592896510","authors":[],"funders":[],"total_grants":0,"fwci":2.4556,"citation_percentile":0.89142585,"influential_citations":0,"citation_trend":[{"year":2017,"count":3},{"year":2018,"count":5},{"year":2019,"count":4},{"year":2020,"count":3},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0039606017300806?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0039606017300806?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.surg.2017.01.019","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28262254","host_type":"repository"}],"fields_of_study":["Neuroendocrine Tumor Research Advances","Breast Lesions and Carcinomas","Lung Cancer Research Studies"],"mesh_terms":["Female","Humans","Male","Middle Aged","Pancreatectomy","Pancreatic Neoplasms","Prospective Studies","Sensitivity and Specificity","Biomarkers, Tumor","Neuroendocrine Tumors","Tumor Burden","Chromogranin A"],"keywords":["Chromogranin A","Neuroendocrine tumors","Medicine","Pancreas","Pancreatic neuroendocrine tumor","Pancreatic tumor","Internal medicine","Gastroenterology","Pancreatic disease","Pathology","Pancreatic cancer","Immunohistochemistry","Cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T17:37:13.483642Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}