{"doi":"10.1016/j.surg.2007.06.007","title":"Coordinated, diurnal hexose transporter expression in rat small bowel: Implications for small bowel resection","abstract":null,"journal":"Surgery","year":2008,"id":658628,"datarank":0.5495342469194471,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.0,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1719350,"name":"Corey W. Iqbal","orcid":null,"position":1,"is_corresponding":false},{"id":1719352,"name":"Judith A. Duenes","orcid":null,"position":2,"is_corresponding":false},{"id":1719354,"name":"Javairiah Fatima","orcid":null,"position":3,"is_corresponding":false},{"id":1719357,"name":"Michael S. Kasparek","orcid":null,"position":4,"is_corresponding":false},{"id":70308,"name":"Michael G. Sarr","orcid":null,"position":5,"is_corresponding":false},{"id":1719348,"name":"Scott G. Houghton","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Coordinated, diurnal hexose transporter expression in rat small bowel: Implications for small bowel resection","abstract":"<h4>Background</h4>Hexose transporter mRNA and protein levels follow a diurnal rhythm in rat jejunum. Their coordinated expression and resultant function throughout the small bowel is not well understood. We hypothesized that hexose transporter levels and glucose absorption follow a coordinated, site-specific diurnal rhythm in rat duodenum and jejunum, but not in ileum.<h4>Methods</h4>Sprague-Dawley rats were housed in a strictly maintained, 12-h, light/dark room [light 6 am to 6 pm] with free access to water and chow. Mucosa was harvested from duodenum, jejunum, and ileum at 3 am, 9 am, 3 pm, and 9 pm, and full thickness 1-cm segments were harvested at 9 am, and 9 pm (n = 6 for each segment at each time point). mRNA levels were determined by reverse-transcription, real-time polymerase chain reaction (n > or = 5), protein levels by semiquantitative Western blotting (n > or = 5), and transporter-mediated glucose uptake by everted sleeve technique (n = 6).<h4>Results</h4>mRNA levels of SGLT1 and GLUT5 followed a temporally coordinated, diurnal rhythm in all 3 segments (P < .01), while mRNA for GLUT2 and protein levels for SGLT1 and GLUT2 varied diurnally only in duodenum and jejunum (P > .05) but not in ileum (P > .10). SGLT1 and GLUT5 mRNA induction decreased aborally. Baseline SGLT1 and GLUT5 mRNA levels and SLGT1 and GLUT2 protein levels did not vary aborally (P > .05 for all). GLUT2 mRNA baseline levels were decreased in ileum (P < .01). Glucose uptake varied diurnally in duodenum and jejunum with no difference in ileum. Transporter-mediated glucose uptake was greater in duodenum and jejunum compared with ileum.<h4>Conclusion</h4>Regulation of hexose absorption in rat small bowel seems to be site-specific and mediated by multiple mechanisms.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18154936","pmcid":"PMC2213714","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK039337","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK39337","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2213714","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0039606007003662?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0039606007003662?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Intestine, Small","Duodenum","Jejunum","Animals","Rats","Rats, Sprague-Dawley","Glucose","Monosaccharide Transport Proteins","RNA, Messenger","Absorption","Circadian Rhythm","Male","Sodium-Glucose Transporter 1","Glucose Transporter Type 2","Glucose Transporter Type 5"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T04:51:51.358516Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}