{"doi":"10.1016/j.stlm.2023.100120","title":"Computational modeling of probiotic recovery from 3D-bioprinted scaffolds for localized vaginal application","abstract":"A variety of bacterial species, including lactobacilli, play a beneficial role in the female reproductive tract (FRT), regulating pH via lactic acid metabolism to help maintain a healthy environment. Bacterial vaginosis (BV) is characterized by a dysregulated flora in which anaerobes such as Gardnerella vaginalis (Gardnerella) predominate. Current treatment focuses on antibiotic administration, including metronidazole, clindamycin, or tinidazole; however, lack of patient compliance and antibiotic resistance may contribute to 50% recurrence within a year. Recently, beneficial (probiotic) bacteria such as Lactobacillus crispatus (L. crispatus) locally administered have been evaluated as a prophylactic against recurrence. To mitigate the lack of patient compliance, sustained probiotic delivery has been proposed via 3D-bioprinted delivery vehicles. Successful delivery depends on a variety of vehicle fabrication parameters influencing timing and rate of probiotic recovery; evaluation of these parameters would benefit from computational modeling complementary to experimental evaluation. This study implements a novel simulation platform to evaluate and predict sustained delivery of probiotics from 3D-bioprinted scaffolds, taking into consideration bacterial lactic acid production and associated pH changes. Results show that the timing and rate of probiotic recovery can be realistically simulated based on fabrication parameters that affect scaffold degradation and probiotic survival. Longer term, the proposed approach could help personalize localized probiotic delivery to the FRT to advance women's health.","journal":"Annals of 3D Printed Medicine","year":2023,"id":362453,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1048429,"name":"Anthony J. Kyser","orcid":"0000-0002-4464-3273","position":1,"is_corresponding":false},{"id":758370,"name":"Dylan A. Goodin","orcid":"0000-0001-9072-7411","position":2,"is_corresponding":false},{"id":439274,"name":"Mohamed Y. Mahmoud","orcid":"0000-0002-7084-2604","position":3,"is_corresponding":false},{"id":439276,"name":"Jill M. Steinbach-Rankins","orcid":"0000-0002-1393-6911","position":4,"is_corresponding":false},{"id":398122,"name":"Hermann B. Frieboes","orcid":"0000-0001-5959-4286","position":5,"is_corresponding":false},{"id":1116009,"name":"Veeresh Rai","orcid":null,"position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:14:19.266946Z","pmid":"37583971","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}