{"doi":"10.1016/j.stemcr.2026.102854","title":"Cellular immunotherapy for COVID-19-induced acute respiratory distress syndrome: Results of the CIRCA-19 phase 1 safety and phase 2 randomized controlled trials","abstract":null,"journal":"Stem Cell Reports","year":2026,"id":626699,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":7314,"name":"Dean A. 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We assessed whether freshly cultured umbilical cord (UC)-derived MSCs improved outcomes in patients with severe COVID-19 ARDS. We enrolled 37 patients with severe COVID-19 ARDS: 15 in the phase 1 dose escalation and open label extension studies (NCT04400032), and 22 patients in the phase 2b randomized clinical trial (NCT04865107). Delivery of up to 270 × 10 6 MSCs in three divided daily doses was well tolerated and resulted in qualitative improvement in all clinical outcomes. Furthermore, MSCs resulted in resolution of lymphopenia, consistent with an important immunomodulatory effect, with significant improvement in patient reported quality-of-life measures (SF-36) at 6 months pointing to possible durable clinical effects. These findings suggest a potential benefit of freshly cultured, UC-MSCs in severe COVID-19 ARDS, associated with biological evidence of favorable immunomodulatory activity.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41825447","pmcid":"PMC13083786","openalex_id":"https://openalex.org/W7135028841","authors":[],"funders":[{"funder_name":"Canadian Institutes of Health Research","grant_id":"172654","title":null},{"funder_name":"Ontario Research Foundation","grant_id":"C-097-2425756-STEWART","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Bundesministerium für Forschung, Technologie und Raumfahrt","grant_id":"","title":null},{"funder_name":"Stem Cell Network","grant_id":"","title":null}],"total_grants":5,"fwci":23.4624,"citation_percentile":0.995035,"influential_citations":0,"citation_trend":[{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.stemcr.2026.102854","host_type":"journal"},{"url":"https://doi.org/10.1016/j.stemcr.2026.102854","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2213671126000652?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2213671126000652?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41825447","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13083786/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC13083786","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC13083786?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Long-Term Effects of COVID-19","COVID-19 Clinical Research Studies","SARS-CoV-2 and COVID-19 Research","0303 health sciences","03 medical and health sciences","Humans","COVID-19","Respiratory Distress Syndrome","Female","SARS-CoV-2","Mesenchymal Stem Cells","Middle Aged","Mesenchymal Stem Cell Transplantation","Male","Adult","Aged","Treatment Outcome","Umbilical Cord","Immunotherapy","Quality of Life","Lymphopenia"],"mesh_terms":["COVID-19","SARS-CoV-2","Adult","Aged","Female","Humans","Immunotherapy","Lymphopenia","Male","Middle Aged","Quality of Life","Respiratory Distress Syndrome","Umbilical Cord","Treatment Outcome","Mesenchymal Stem Cell Transplantation","Mesenchymal Stem Cells"],"keywords":["Acute respiratory distress","Randomized controlled trial","Immunotherapy","Phase (matter)","Clinical trial","Phases of clinical research","Immunomodulation","Cell therapy","Acute respiratory distress syndrome","Mesenchymal Stem Cells","Lymphopenia","Randomized Clinical Trial","Covid-19","Sars-cov2"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T14:53:11.060144Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}