{"doi":"10.1016/j.stemcr.2025.102691","title":"Circadian regulation of insulin secretion in transplanted human stem cell-derived pancreatic β-cells","abstract":"Cell replacement strategies utilizing stem cell-derived pancreatic β-cells (SCβ-cells) hold therapeutic potential for patients with diabetes. However, little is known about how endogenous (host) and exogenous (transplant) circadian systems interact to influence the engraftment and function of SCβ-cells. We report that differentiation of SCβ-cells in vitro is associated with the induction of key circadian clock genes known to regulate insulin secretion. Upon transplantation into severe combined immunodeficiency (SCID)-beige mice, SCβ-cells exhibit circadian rhythms in glucose-stimulated insulin secretion optimized to the host's active circadian phase. Furthermore, disrupting the host's circadian rhythms abolishes circadian regulation and the overall functional capacity of transplanted SCβ-cells. These observations suggest that the host's circadian system entrains SCβ-cell function to optimize the circadian control of insulin secretion.","journal":"Stem Cell Reports","year":2025,"id":579556,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9587,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":436162,"name":"Zenith Khashim","orcid":"0000-0002-1291-573X","position":1,"is_corresponding":false},{"id":1490129,"name":"Sharath Shivakumar Belame","orcid":null,"position":2,"is_corresponding":false},{"id":283428,"name":"Shaimaa Hassoun","orcid":null,"position":3,"is_corresponding":false},{"id":1187235,"name":"Tiana Salomon","orcid":null,"position":4,"is_corresponding":false},{"id":1400607,"name":"Sean Lewis-Brinkman","orcid":null,"position":5,"is_corresponding":false},{"id":281311,"name":"Matthew Brown","orcid":"0000-0001-7429-2657","position":6,"is_corresponding":false},{"id":364481,"name":"Luhui Zhang","orcid":"0000-0002-6002-6574","position":7,"is_corresponding":false},{"id":281308,"name":"Quinn P. Peterson","orcid":"0000-0001-8701-0575","position":8,"is_corresponding":false},{"id":241936,"name":"Aleksey V. Matveyenko","orcid":"0000-0001-7761-4842","position":9,"is_corresponding":false},{"id":473669,"name":"Satish Sen","orcid":"0000-0002-0950-9722","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:58:30.282164Z","pmid":"41173007","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}