{"doi":"10.1016/j.stemcr.2024.01.005","title":"Human iPSC-derived photoreceptor transplantation in the cone dominant 13-lined ground squirrel","abstract":"Several retinal degenerations affect the human central retina, which is primarily comprised of cones and is essential for high acuity and color vision. Transplanting cone photoreceptors is a promising strategy to replace degenerated cones in this region. Although this approach has been investigated in a handful of animal models, commonly used rodent models lack a cone-rich region and larger models can be expensive and inaccessible, impeding the translation of therapies. Here, we transplanted dissociated GFP-expressing photoreceptors from retinal organoids differentiated from human induced pluripotent stem cells into the subretinal space of damaged and undamaged cone-dominant 13-lined ground squirrel eyes. Transplanted cell survival was documented via noninvasive high-resolution imaging and immunohistochemistry to confirm the presence of human donor photoreceptors for up to 4 months posttransplantation. These results demonstrate the utility of a cone-dominant rodent model for advancing the clinical translation of cell replacement therapies.","journal":"Stem Cell Reports","year":2024,"id":424921,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":869628,"name":"Sangeetha Kandoi","orcid":"0000-0001-8346-8642","position":1,"is_corresponding":false},{"id":722695,"name":"Ramesh Periasamy","orcid":null,"position":2,"is_corresponding":false},{"id":1085200,"name":"L Vinod K. Reddy","orcid":null,"position":3,"is_corresponding":false},{"id":1222014,"name":"Hannah M. Follett","orcid":"0000-0002-7221-2286","position":4,"is_corresponding":false},{"id":335894,"name":"Phyllis Summerfelt","orcid":null,"position":5,"is_corresponding":false},{"id":1084611,"name":"Cassandra Martinez","orcid":"0000-0003-4899-8888","position":6,"is_corresponding":false},{"id":1222015,"name":"C. Guillaume","orcid":"0000-0002-9732-2975","position":7,"is_corresponding":false},{"id":1222535,"name":"Owen R. Bowie","orcid":null,"position":8,"is_corresponding":false},{"id":335078,"name":"Thomas B. Connor","orcid":"0009-0001-2679-2910","position":9,"is_corresponding":false},{"id":768166,"name":"Daniel M. Lipinski","orcid":"0000-0001-7828-614X","position":10,"is_corresponding":false},{"id":1222016,"name":"Kenneth P. Allen","orcid":"0000-0002-7360-437X","position":11,"is_corresponding":false},{"id":768165,"name":"Dana K. Merriman","orcid":"0000-0003-2780-0772","position":12,"is_corresponding":false},{"id":335079,"name":"Joseph Carroll","orcid":"0000-0002-8640-1029","position":13,"is_corresponding":false},{"id":411804,"name":"Deepak A. Lamba","orcid":"0000-0002-2811-307X","position":14,"is_corresponding":false},{"id":1222013,"name":"Ching Tzu Yu","orcid":"0000-0003-4117-1837","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T01:58:21.523756Z","pmid":"38335965","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}