{"doi":"10.1016/j.stemcr.2023.07.002","title":"VE-CADHERIN is expressed transiently in early ISL1+ cardiovascular progenitor cells and facilitates cardiac differentiation","abstract":"Adherens junctions (AJs) provide adhesive properties through cadherins and associated cytoplasmic catenins and participate in morphogenetic processes. We examined AJs formed between ISL1 + cardiovascular progenitor cells during differentiation of embryonic stem cells (ESCs) in vitro and in mouse embryogenesis in vivo . We found that, in addition to N-CADHERIN, a percentage of ISL1 + cells transiently formed vascular endothelial (VE)-CADHERIN-mediated AJs during in vitro differentiation on days 4 and 5, and the same pattern was observed in vivo . Fluorescence-activated cell sorting (FACS) analysis extended morphological data showing that VE-CADHERIN + /ISL1 + cells constitute a significant percentage of cardiac progenitors on days 4 and 5. The VE-CADHERIN + /ISL1 + cell population represented one-third of the emerging FLK1 + /PDGFRa + cardiac progenitor cells (CPCs) for a restricted time window (days 4–6). Ablation of VE-CADHERIN during ESC differentiation results in severe inhibition of cardiac differentiation. Disruption of all classic cadherins in the VE-CADHERIN + population via a cadherin dominant-negative mutant's expression resulted in a dramatic decrease in the ISL1 + population and inhibition of cardiac differentiation.","journal":"Stem Cell Reports","year":2023,"id":368659,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1127033,"name":"Anna N. Melidoni","orcid":"0000-0002-2535-883X","position":1,"is_corresponding":false},{"id":796942,"name":"Dimitris Beis","orcid":"0000-0003-2579-7848","position":2,"is_corresponding":false},{"id":1127034,"name":"Ioannis Kokkinopoulos","orcid":"0000-0002-8143-6695","position":3,"is_corresponding":false},{"id":1127035,"name":"Nikolaos Paschalidis","orcid":"0000-0001-6278-4144","position":4,"is_corresponding":false},{"id":1127036,"name":"Panos Kouklis","orcid":"0000-0003-0378-5619","position":5,"is_corresponding":false},{"id":1127477,"name":"Violetta Maltabe","orcid":null,"position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T01:15:24.517012Z","pmid":"37541259","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}