{"doi":"10.1016/j.stemcr.2023.03.013","title":"IRX5 promotes DNA damage repair and activation of hair follicle stem cells","abstract":"The molecular mechanisms allowing hair follicles to periodically activate their stem cells (HFSCs) are incompletely characterized. Here, we identify the transcription factor IRX5 as a promoter of HFSC activation. Irx5 −/− mice have delayed anagen onset, with increased DNA damage and diminished HFSC proliferation. Open chromatin regions form near cell cycle progression and DNA damage repair genes in Irx5 −/− HFSCs. DNA damage repair factor BRCA1 is an IRX5 downstream target. Inhibition of FGF kinase signaling partially rescues the anagen delay in Irx5 −/− mice, suggesting that the Irx5 −/− HFSC quiescent phenotype is partly due to failure to suppress Fgf18 expression. Interfollicular epidermal stem cells also show decreased proliferation and increased DNA damage in Irx5 −/− mice. Consistent with a role for IRX5 as a promoter of DNA damage repair, we find that IRX genes are upregulated in many cancer types and that there is a correlation between IRX5 and BRCA1 expression in breast cancer.","journal":"Stem Cell Reports","year":2023,"id":363826,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":886098,"name":"Julie Wiedemann","orcid":"0000-0002-5293-031X","position":1,"is_corresponding":false},{"id":1118250,"name":"Ly Thi Huong Nguyen","orcid":"0000-0003-0567-2562","position":2,"is_corresponding":false},{"id":321173,"name":"Zhongqi Lin","orcid":"0000-0002-4806-0091","position":3,"is_corresponding":false},{"id":1118625,"name":"Mahum Tahir","orcid":null,"position":4,"is_corresponding":false},{"id":406281,"name":"Chi‐chung Hui","orcid":"0000-0001-7047-6694","position":5,"is_corresponding":false},{"id":19468,"name":"Maksim V. Plikus","orcid":"0000-0002-8845-2559","position":6,"is_corresponding":false},{"id":308697,"name":"Bogi Andersen","orcid":"0000-0001-7181-2768","position":7,"is_corresponding":false},{"id":923803,"name":"Jefferson K. Chen","orcid":"0000-0002-9175-8305","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:14:32.510714Z","pmid":"37084727","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}