{"doi":"10.1016/j.stemcr.2022.06.009","title":"Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs","abstract":"Regenerative therapies aimed at replacing photoreceptors are a promising approach for the treatment of otherwise incurable causes of blindness. However, such therapies still face significant hurdles, including the need to improve subretinal delivery and long-term survival rate of transplanted cells, and promote sufficient integration into the host retina. Here, we successfully delivered in vitro-derived human photoreceptor precursor cells (PRPCs; also known as immature photoreceptors) to the subretinal space of seven normal and three rcd1/PDE6B mutant dogs with advanced inherited retinal degeneration. Notably, while these xenografts were rejected in dogs that were not immunosuppressed, transplants in most dogs receiving systemic immunosuppression survived up to 3-5 months postinjection. Moreover, differentiation of donor PRPCs into photoreceptors with synaptic pedicle-like structures that established contact with second-order neurons was enhanced in rcd1/PDE6B mutant dogs. Together, our findings set the stage for evaluating functional vision restoration following photoreceptor replacement in canine models of inherited retinal degeneration.","journal":"Stem Cell Reports","year":2022,"id":239088,"datarank":0.5955437870328184,"base_score":3.970291913552122,"endowment":3.970291913552122,"self_citation_contribution":0.5955437870328184,"citation_network_contribution":0.0,"self_endowment_contribution":0.5955437870328184,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":451216,"name":"Natalia V. Dolgova","orcid":"0000-0002-9951-6634","position":1,"is_corresponding":false},{"id":280704,"name":"M. Joseph Phillips","orcid":"0000-0001-8701-2386","position":2,"is_corresponding":false},{"id":322206,"name":"Svetlana Savina","orcid":null,"position":3,"is_corresponding":false},{"id":347163,"name":"Allison L. Ludwig","orcid":"0000-0002-3327-9795","position":4,"is_corresponding":false},{"id":347162,"name":"Sara A. Stuedemann","orcid":"0009-0007-7579-3016","position":5,"is_corresponding":false},{"id":865196,"name":"Uchenna Nlebedum","orcid":null,"position":6,"is_corresponding":false},{"id":497427,"name":"John H. Wolfe","orcid":"0000-0002-7497-3943","position":7,"is_corresponding":false},{"id":449753,"name":"Oliver A. Garden","orcid":"0000-0002-4133-9487","position":8,"is_corresponding":false},{"id":294129,"name":"Arvydas Maminishkis","orcid":"0000-0003-3345-3375","position":9,"is_corresponding":false},{"id":864334,"name":"Juan Amaral","orcid":"0000-0001-8755-9170","position":10,"is_corresponding":false},{"id":277735,"name":"Kapil Bharti","orcid":"0000-0003-4884-3173","position":11,"is_corresponding":false},{"id":280706,"name":"David M. Gamm","orcid":"0000-0002-8152-613X","position":12,"is_corresponding":false},{"id":260097,"name":"Geoffrey K. Aguirre","orcid":"0000-0002-4028-3100","position":13,"is_corresponding":false},{"id":340094,"name":"William A. Beltran","orcid":"0000-0002-1127-4774","position":14,"is_corresponding":false},{"id":584653,"name":"Ana Ripolles‐Garcia","orcid":"0000-0002-7132-2491","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:22:36.865157Z","pmid":"35905738","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}