{"doi":"10.1016/j.stemcr.2021.08.018","title":"Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells","abstract":"The pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been attributed to its ability to enter through the membrane-bound angiotensin-converting enzyme 2 (ACE2) receptor. Therefore, it has been heavily speculated that angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy may modulate SARS-CoV-2 infection. In this study, exposure of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and human endothelial cells (hECs) to SARS-CoV-2 identified significant differences in protein coding genes involved in immunity, viral response, and cardiomyocyte/endothelial structure. Specifically, transcriptome changes were identified in the tumor necrosis factor (TNF), interferon α/β, and mitogen-activated protein kinase (MAPK) (hPSC-CMs) as well as nuclear factor kappa-B (NF-κB) (hECs) signaling pathways. However, pre-treatment of hPSC-CMs or hECs with two widely prescribed antihypertensive medications, losartan and lisinopril, did not affect the susceptibility of either cell type to SARS-CoV-2 infection. These findings demonstrate the toxic effects of SARS-CoV-2 in hPSC-CMs/hECs and, taken together with newly emerging multicenter trials, suggest that antihypertensive drug treatment alone does not alter SARS-CoV-2 infection.","journal":"Stem Cell Reports","year":2021,"id":179716,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":728030,"name":"Sobhi G. Kazmouz","orcid":null,"position":1,"is_corresponding":false},{"id":635394,"name":"Shuaizhi Li","orcid":null,"position":2,"is_corresponding":false},{"id":727445,"name":"Ben N. Stansfield","orcid":"0000-0003-2061-9428","position":3,"is_corresponding":false},{"id":728031,"name":"Tori T. Salem","orcid":null,"position":4,"is_corresponding":false},{"id":254854,"name":"Samantha Perez‐Miller","orcid":"0000-0002-9034-3693","position":5,"is_corresponding":false},{"id":727446,"name":"Toshinobu Kazui","orcid":"0000-0003-1501-9639","position":6,"is_corresponding":false},{"id":727447,"name":"Lipsa Jena","orcid":"0000-0002-4998-4050","position":7,"is_corresponding":false},{"id":231625,"name":"Jennifer L. Uhrlaub","orcid":"0000-0002-7745-0179","position":8,"is_corresponding":false},{"id":558295,"name":"Scott D. Lick","orcid":null,"position":9,"is_corresponding":false},{"id":231647,"name":"Janko Nikolich‐Žugich","orcid":"0000-0001-5830-5323","position":10,"is_corresponding":false},{"id":342066,"name":"John P. Konhilas","orcid":"0000-0002-3579-087X","position":11,"is_corresponding":false},{"id":364701,"name":"Carol C. Gregorio","orcid":"0000-0002-0044-2074","position":12,"is_corresponding":false},{"id":727448,"name":"May Khanna","orcid":"0000-0002-9989-6374","position":13,"is_corresponding":false},{"id":557630,"name":"Samuel K. Campos","orcid":"0000-0003-1540-9821","position":14,"is_corresponding":false},{"id":278205,"name":"Jared M. Churko","orcid":"0000-0003-3537-9834","position":15,"is_corresponding":false},{"id":727444,"name":"Jessika Iwanski","orcid":"0000-0003-2482-5376","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":null,"created_at":"2026-07-18T23:47:48.974996Z","pmid":"34525378","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}