{"doi":"10.1016/j.stemcr.2020.07.004","title":"A Single Radioprotective Dose of Prostaglandin E2 Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells","abstract":"Ionizing radiation exposure results in acute and delayed bone marrow suppression. Treatment of mice with 16,16-dimethyl prostaglandin E 2 (dmPGE 2 ) prior to lethal ionizing radiation (IR) facilitates survival, but the cellular and molecular mechanisms are unclear. In this study we show that dmPGE 2 attenuates loss and enhances recovery of bone marrow cellularity, corresponding to a less severe hematopoietic stem cell nadir, and significantly preserves long-term repopulation capacity and progenitor cell function. Mechanistically, dmPGE 2 suppressed hematopoietic stem cell (HSC) proliferation through 24 h post IR, which correlated with fewer DNA double-strand breaks and attenuation of apoptosis, mitochondrial compromise, oxidative stress, and senescence. RNA sequencing of HSCs at 1 h and 24 h post IR identified a predominant interference with IR-induced p53-downstream gene expression at 1 h, and confirmed the suppression of IR-induced cell-cycle genes at 24 h. These data identify mechanisms of dmPGE 2 radioprotection and its potential role as a medical countermeasure against radiation exposure.","journal":"Stem Cell Reports","year":2020,"id":93388,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":288465,"name":"Liqiong Liu","orcid":"0000-0002-2680-4360","position":1,"is_corresponding":false},{"id":415181,"name":"Carol H. Sampson","orcid":null,"position":2,"is_corresponding":false},{"id":415184,"name":"P. Artur Plett","orcid":null,"position":3,"is_corresponding":false},{"id":466123,"name":"Hongge Li","orcid":"0000-0002-4032-5729","position":4,"is_corresponding":false},{"id":312164,"name":"Pratibha Singh","orcid":"0000-0002-6571-1271","position":5,"is_corresponding":false},{"id":312165,"name":"Khalid S. Mohammad","orcid":"0009-0006-9708-2111","position":6,"is_corresponding":false},{"id":466124,"name":"Jonathan Hoggatt","orcid":"0000-0002-6416-1634","position":7,"is_corresponding":false},{"id":419911,"name":"Maegan L. Capitano","orcid":"0000-0002-5210-5221","position":8,"is_corresponding":false},{"id":341460,"name":"Christie M. Orschell","orcid":"0000-0002-3679-2180","position":9,"is_corresponding":false},{"id":312166,"name":"Louis M. Pelus","orcid":"0000-0001-8376-4425","position":10,"is_corresponding":false},{"id":414556,"name":"Andrea M. Patterson","orcid":"0000-0002-3000-1157","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-18T22:30:54.208860Z","pmid":"32735825","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}