{"doi":"10.1016/j.stemcr.2017.10.025","title":"Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair","abstract":null,"journal":"Stem Cell Reports","year":2017,"id":607582,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":779853,"name":"Khalid Algarrahi","orcid":null,"position":1,"is_corresponding":false},{"id":1560178,"name":"Alyssa Savarino","orcid":null,"position":2,"is_corresponding":false},{"id":779362,"name":"Xuehui Yang","orcid":"0000-0002-8049-1326","position":3,"is_corresponding":false},{"id":1560180,"name":"Catherine Seager","orcid":null,"position":4,"is_corresponding":false},{"id":1560182,"name":"Debra Franck","orcid":null,"position":5,"is_corresponding":false},{"id":779854,"name":"Kyle Costa","orcid":null,"position":6,"is_corresponding":false},{"id":1300385,"name":"Shanshan Liu","orcid":"0009-0009-6952-0817","position":7,"is_corresponding":false},{"id":770949,"name":"Tanya Logvinenko","orcid":null,"position":8,"is_corresponding":false},{"id":1560186,"name":"Rosalyn Adam","orcid":null,"position":9,"is_corresponding":false},{"id":767910,"name":"Joshua R. 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We demonstrate using lineage-tracing systems that urothelial regeneration following augmentation cystoplasty with acellular grafts exclusively depends on host keratin 5-expressing basal cells to repopulate all lineages of the de novo urothelium at implant sites. Conversely, repair of focal mucosal defects not only employs this mechanism, but in parallel host intermediate cell daughters expressing uroplakin 2 give rise to themselves and are also contributors to superficial cells in neotissues. These results highlight the diversity of urothelial regenerative responses to surgical injury and may lead to advancements in bladder tissue engineering approaches.","is_dataset_classified":null,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29173895","pmcid":"PMC5785709","openalex_id":"https://openalex.org/W2769136886","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"T32 DK060442","title":null},{"funder_name":"Rainmaker Group","grant_id":"","title":null},{"funder_name":"Max Kade Foundation","grant_id":"","title":null}],"total_grants":3,"fwci":1.6543,"citation_percentile":0.84283361,"influential_citations":0,"citation_trend":[{"year":2018,"count":2},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":7},{"year":2022,"count":3},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.cell.com/article/S2213671117304800/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S2213671117304800/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2213671117304800?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2213671117304800?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.stemcr.2017.10.025","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29173895","host_type":"repository"},{"url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868772","host_type":"repository"},{"url":"https://doaj.org/article/c216935ead3847d2a3881b54f08951d0","host_type":"repository"},{"url":"https://escholarship.org/uc/item/6vj4s2j7","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5785709","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5785709","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5785709?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Tissue Engineering and Regenerative Medicine","Urological Disorders and Treatments","Bladder and Urothelial Cancer Treatments"],"mesh_terms":["Animals","Urinary Bladder","Cell Differentiation","Humans","Intraoperative Complications","Regeneration","Urine","Gene Expression Regulation, Developmental","Cell Lineage","Urothelium","Tissue Engineering","Mice","Keratin-5","Cell Tracking","Uroplakin II"],"keywords":["Urothelium","Biology","Keratin 5","Regeneration (biology)","Submucosa","Urothelial Cell","Blastema","Bladder augmentation","Urinary bladder","Epithelium","Progenitor cell","Anatomy","Pathology","Stem cell","Keratin","Cell biology","Urology","Urinary system","Medicine","Bladder","Tissue engineering","Progenitor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"hpa"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T06:38:56.946886Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}