{"doi":"10.1016/j.stem.2024.01.011","title":"An iron rheostat controls hematopoietic stem cell fate","abstract":"Mechanisms governing the maintenance of blood-producing hematopoietic stem and multipotent progenitor cells (HSPCs) are incompletely understood, particularly those regulating fate, ensuring long-term maintenance, and preventing aging-associated stem cell dysfunction. We uncovered a role for transitory free cytoplasmic iron as a rheostat for adult stem cell fate control. We found that HSPCs harbor comparatively small amounts of free iron and show the activation of a conserved molecular response to limited iron-particularly during mitosis. To study the functional and molecular consequences of iron restriction, we developed models allowing for transient iron bioavailability limitation and combined single-molecule RNA quantification, metabolomics, and single-cell transcriptomic analyses with functional studies. Our data reveal that the activation of the limited iron response triggers coordinated metabolic and epigenetic events, establishing stemness-conferring gene regulation. Notably, we find that aging-associated cytoplasmic iron loading reversibly attenuates iron-dependent cell fate control, explicating intervention strategies for dysfunctional aged stem cells.","journal":"Cell stem cell","year":2024,"id":418847,"datarank":1.0068437131064287,"base_score":3.828641396489095,"endowment":3.828641396489095,"self_citation_contribution":0.5742962094733643,"citation_network_contribution":0.4325475036330644,"self_endowment_contribution":0.5742962094733643,"citer_contribution":0.4325475036330644,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":42,"citers_with_citation_signal":25,"citers_with_endowment":25,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":692378,"name":"Jiahao Chen","orcid":"0000-0001-7719-3216","position":1,"is_corresponding":false},{"id":692372,"name":"Rajni Kumari","orcid":"0000-0003-2735-3749","position":2,"is_corresponding":false},{"id":35782,"name":"Anita Ng","orcid":"0000-0001-8203-667X","position":3,"is_corresponding":false},{"id":620190,"name":"Aliona Zintiridou","orcid":"0000-0001-9780-6083","position":4,"is_corresponding":false},{"id":930676,"name":"Madhuri Tatiparthy","orcid":"0000-0001-8542-2218","position":5,"is_corresponding":false},{"id":1134917,"name":"Yuhong Ma","orcid":"0000-0002-0134-3481","position":6,"is_corresponding":false},{"id":899554,"name":"Maria M. Aivalioti","orcid":"0000-0003-3462-5626","position":7,"is_corresponding":false},{"id":1208060,"name":"Deeposree Moulik","orcid":null,"position":8,"is_corresponding":false},{"id":520758,"name":"Sriram Sundaravel","orcid":"0000-0003-1638-710X","position":9,"is_corresponding":false},{"id":693156,"name":"Daqian Sun","orcid":null,"position":10,"is_corresponding":false},{"id":110268,"name":"Julie A. Reisz","orcid":"0000-0002-7296-4963","position":11,"is_corresponding":false},{"id":1207426,"name":"Juliane Grimm","orcid":"0000-0002-4354-592X","position":12,"is_corresponding":false},{"id":1005085,"name":"Nuria Martínez-López","orcid":"0000-0002-8220-6015","position":13,"is_corresponding":false},{"id":563067,"name":"Stephanie Stransky","orcid":"0000-0003-0844-2754","position":14,"is_corresponding":false},{"id":247704,"name":"Simone Sidoli","orcid":"0000-0001-9073-6641","position":15,"is_corresponding":false},{"id":268425,"name":"Ulrich Steidl","orcid":"0000-0002-9458-1795","position":16,"is_corresponding":false},{"id":740844,"name":"Rajat Singh","orcid":"0000-0001-9389-8574","position":17,"is_corresponding":false},{"id":28360,"name":"Angelo D’Alessandro","orcid":"0000-0002-2258-6490","position":18,"is_corresponding":false},{"id":620191,"name":"Britta Will","orcid":"0000-0002-9534-6690","position":19,"is_corresponding":false},{"id":620188,"name":"Yun-Ruei Kao","orcid":"0000-0002-0119-8827","position":0,"is_corresponding":true}],"reference_count":196,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:57:09.067930Z","pmid":"38402617","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}