{"doi":"10.1016/j.smim.2025.102005","title":"IL-1 family members as regulators of lymphoid type-2 immunity in cancer","abstract":null,"journal":"Seminars in Immunology","year":2026,"id":670522,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1751480,"name":"Filippo Colombo","orcid":null,"position":1,"is_corresponding":false},{"id":1751482,"name":"Lucia De Monte","orcid":null,"position":2,"is_corresponding":false},{"id":1751484,"name":"Maria Pia Protti","orcid":"0000-0001-9079-2336","position":3,"is_corresponding":false},{"id":1734671,"name":"Stefania Roma","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"IL-1 family members as regulators of lymphoid type-2 immunity in cancer","abstract":"IL-1 family members, such as IL-1 and IL-33, are present in the tumor microenvironment and exert tumor-intrinsic and tumor-extrinsic functions with both pro- and anti-tumor effects. Among their immunoregulatory roles, both cytokines contribute to lymphoid type-2 immunity. IL-1 can indirectly promote CD4<sup>+</sup> Th2 responses by inducing thymic stromal lymphopoietin production by tumor cells or cancer associated fibroblasts that conditions Th2-polarizing dendritic cells, whereas IL-33 is a potent direct activator of CD4<sup>+</sup> Th2 and other type-2 immune cells, such as group 2 innate lymphoid cells (ILC2s). In a large majority of established human cancers, CD4<sup>+</sup> Th2 cell responses correlate with tumor-promotion, whereas expansion of ILC2s can either suppress or promote tumor immunity in a more balanced way, leading to tumor progression or regression. Interestingly, the two prototypical Th2 cytokines IL-13 and IL-5 exert apparently pro- and anti-tumor opposing functions by recruitment of myeloid-derived cells and eosinophils, respectively. In addition, anti-tumor ILC2s under the influence of the tumor microenvironment may become dysfunctional, ultimately resulting in tumor-progression. Understanding the specific cancer context and considering the similarities as well as the distinctive features of the two lymphoid type-2 cell subsets is essential for developing effective immunotherapeutic strategies by targeting the IL-1 and IL-33 cytokines.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41317636","pmcid":null,"openalex_id":"https://openalex.org/W4416795662","authors":[],"funders":[{"funder_name":"Italian Association for Cancer Research","grant_id":"22737","title":null}],"total_grants":1,"fwci":0.0,"citation_percentile":0.36043488,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1044532325000776?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1044532325000776?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.smim.2025.102005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41317636","host_type":"repository"}],"fields_of_study":["IL-33, ST2, and ILC Pathways","Immune Cell Function and Interaction","Eosinophilic Esophagitis","Humans","Neoplasms","Tumor Microenvironment","Animals","Interleukin-1","Immunity, Innate","Th2 Cells","Interleukin-33","Lymphocytes"],"mesh_terms":["Interleukin-33","Animals","Humans","Immunity, Innate","Interleukin-1","Lymphocytes","Neoplasms","Th2 Cells","Tumor Microenvironment"],"keywords":["Thymic stromal lymphopoietin","Innate lymphoid cell","Immune system","Stromal cell","Tumor microenvironment","Immunity","Cancer","Context (archaeology)","T cell","IL-1β","Anti-tumor","Il-33","Il-1α","Pro-tumor","Ilc2 Cells","Cd4(+) Th2 Cells"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-15T22:31:58.587426Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}