{"doi":"10.1016/j.sleep.2024.02.046","title":"The association between the effective apnea-hypopnea index and blood pressure reduction efficacy following CPAP/oxygen treatment","abstract":null,"journal":"Sleep Medicine","year":2024,"id":617609,"datarank":0.36914637402154754,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0772598516632505,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0772598516632505,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1269233,"name":"Fei Lei","orcid":"0000-0003-4291-9413","position":1,"is_corresponding":false},{"id":1067758,"name":"Xiangdong Tang","orcid":"0000-0001-6876-3328","position":2,"is_corresponding":false},{"id":397547,"name":"Zongan Liang","orcid":"0000-0002-8358-9177","position":3,"is_corresponding":false},{"id":1592870,"name":"Robert Joseph Thomas","orcid":null,"position":4,"is_corresponding":false},{"id":398718,"name":"Yue-Nan Ni","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The association between the effective apnea-hypopnea index and blood pressure reduction efficacy following CPAP/oxygen treatment","abstract":"<h4>Background</h4>The effect of sleep apnea treatment on reducing cardiovascular disease risk remains inconclusive. This study aims to assess if the effective apnea hypopnea index (eAHI), a measure of residual sleep apnea burden post-treatment, is a factor in determining blood pressure (BP) response to continuous positive airway pressure therapy. The eAHI integrates time on therapy, residual apnea, and % of sleep time untreated.<h4>Methods</h4>A secondary analysis of the Heart Biomarker Evaluation in Apnea Treatment (HeartBEAT) study, a randomized, controlled, parallel group assessment of continuous positive airway pressure (CPAP), oxygen and sleep hygiene. The Delta-AHI (▲AHI) was defined as the difference between baseline AHI and effective AHI at 12 weeks. Logistic and linear regression models estimated the predictors for nocturnal systolic BP change following sleep apnea therapy.<h4>Results</h4>One hundred and sixty-nine subjects with a mean age of 62.82 ± 6.99 years were included in the final analysis. Fifty subjects had ▲AHI ≤8/hour of sleep and 119 subjects were higher. After adjustment, baseline mean nighttime systolic blood pressure (OR 1.036, 95% CI 1.015-1.058, p: 0.001) and ▲AHI ≥8/hour (OR 2.406, 95% CI 1.116-5.185, p:0.025) were independent predictors for mean nighttime systolic blood pressure change >3 mm Hg. The higher effective AHI was negatively related with BNP (β: -2.564, SE: 1.167, p: 0.029) and positively related with troponin change (β: 0.703, SE: 0.256, p: 0.007).<h4>Conclusion</h4>The ▲AHI was an independent predictor of the blood pressure response to sleep apnea treatment.<h4>Register number</h4>NCT01086800.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38507976","pmcid":null,"openalex_id":"https://openalex.org/W4392767766","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82300118","title":null},{"funder_name":"Sichuan Province Science and Technology Support Program","grant_id":"","title":null},{"funder_name":"American Academy of Sleep Medicine Foundation","grant_id":"","title":null},{"funder_name":"Ministry of Science and Technology of the People&apos;s Republic of China","grant_id":"","title":null}],"total_grants":4,"fwci":1.4691,"citation_percentile":0.81239012,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1389945724000947?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1389945724000947?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.sleep.2024.02.046","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38507976","host_type":"repository"}],"fields_of_study":["Obstructive Sleep Apnea Research","Delphi Technique in Research","Chronic Obstructive Pulmonary Disease (COPD) Research","Humans","Middle Aged","Aged","Blood Pressure","Continuous Positive Airway Pressure","Sleep Apnea, Obstructive","Sleep Apnea Syndromes","Oxygen"],"mesh_terms":["Aged","Blood Pressure","Humans","Middle Aged","Oxygen","Sleep Apnea Syndromes","Sleep Apnea, Obstructive","Continuous Positive Airway Pressure"],"keywords":["Medicine","Blood pressure","Apnea–hypopnea index","Cardiology","Apnea","Index (typography)","Anesthesia","Internal medicine","Polysomnography","Computer science","Oxygen therapy","Sleep Apnea","Positive Airway Pressure","Effective Apnea-hypopnea Index"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T02:11:21.588140Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}