{"doi":"10.1016/j.slast.2024.100234","title":"Notes on AEMS methods development for high throughput experimentation in drug discovery","abstract":"Acoustic-ejection mass spectrometry (AEMS) is a versatile sampling technology that enables high throughput experimentation (HTE) in drug discovery [1,2]. It eliminates pumps, columns and instrumentation associated with a ‘standard’ LCMS workstation. Instead, a novel Open Port Sampling Interface (OPSI) is used to capture and transport acoustically dispensed nanoliter volume droplets to the mass spectrometer for quantitative and/or qualitative analysis. OPSI can handle samples and formats that are amenable to acoustic dispensing, these include biochemical, cell-based, ADME and related screening and reaction-profiling applications used extensively in drug discovery [3].","journal":"SLAS TECHNOLOGY","year":2024,"id":478085,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9618,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1102276,"name":"Nate Hoxie","orcid":"0000-0001-5880-4165","position":1,"is_corresponding":false},{"id":969854,"name":"John Janiszewski","orcid":null,"position":2,"is_corresponding":false},{"id":561233,"name":"Charles Bonney","orcid":null,"position":3,"is_corresponding":false},{"id":255126,"name":"Matthew D. Hall","orcid":"0000-0002-5073-442X","position":4,"is_corresponding":false},{"id":225305,"name":"Sam Michael","orcid":"0000-0002-1070-6563","position":5,"is_corresponding":false},{"id":1250477,"name":"Tom Covey","orcid":null,"position":6,"is_corresponding":false},{"id":268298,"name":"Jonathan H. Shrimp","orcid":"0000-0001-9872-942X","position":7,"is_corresponding":false},{"id":1316591,"name":"Meghav Verma","orcid":"0009-0003-8911-6930","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:06:42.155024Z","pmid":"39638257","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}