{"doi":"10.1016/j.slast.2023.10.003","title":"Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products","abstract":null,"journal":"SLAS Technology","year":2024,"id":641931,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1669325,"name":"José R. 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Mackenzie","orcid":"0009-0000-4297-6966","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products","abstract":"Natural Products (NPs) are one of the main sources for drug discovery. Many clinical drugs are NPs or NP-inspired compounds, and recently discovered New Chemical Entities (NCEs) of NPs are emerging as promising new drugs. High-Throughput Screening (HTS) of large sample sets or libraries has grown to be vital for the drug discovery field. Industrial-scale HTS of NP libraries can be limited due to the difficulties entailed in working with tiny extract volumes and the variability in viscosity of NP extracts. For these reasons, the implementation of new technologies to miniaturize different reagent volumes grows to be fundamental. Since Acoustic Droplet Ejection (ADE) emerged as a helpful tool in HTS campaigns for the transference of compound libraries. The aim of this work was to test the effectiveness of ADE for the dispensation of NP extract libraries in cell-based HTS assays.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37898289","pmcid":null,"openalex_id":"https://openalex.org/W4388007141","authors":[],"funders":[{"funder_name":"Government of Andalusia","grant_id":"INP-2011-0016-PCT-010000-ACT7-2011","title":null}],"total_grants":1,"fwci":0.7987,"citation_percentile":0.66323792,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"http://slas-technology.org/article/S2472630323000626/pdf","host_type":"journal"},{"url":"http://slas-technology.org/article/S2472630323000626/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2472630323000626?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2472630323000626?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.slast.2023.10.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37898289","host_type":"repository"},{"url":"https://doaj.org/article/8fd4b72cc19c459ea5afb4fb95a2858d","host_type":"repository"}],"fields_of_study":["Innovative Microfluidic and Catalytic Techniques Innovation","3D Printing in Biomedical Research","Viral Infectious Diseases and Gene Expression in Insects"],"mesh_terms":["Bacterial Lysates","Acoustics","Biological Products","Drug Evaluation, Preclinical","Fungi","Humans","Pilot Projects","Small Molecule Libraries","Drug Discovery","Hep G2 Cells","High-Throughput Screening Assays"],"keywords":["Throughput","Computer science","Telecommunications","high throughput screening (HTS)","Natural Products (Np)","Acoustic Droplet Ejection (Ade)"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T20:56:43.070045Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}