{"doi":"10.1016/j.slasd.2024.100160","title":"A high-throughput response to the SARS-CoV-2 pandemic","abstract":"Four years after the beginning of the COVID-19 pandemic, it is important to reflect on the events that have occurred during that time and the knowledge that has been gained. The response to the pandemic was rapid and highly resourced; it was also built upon a foundation of decades of federally funded basic and applied research. Laboratories in government, pharmaceutical, academic, and non-profit institutions all played roles in advancing pre-2020 discoveries to produce clinical treatments. This perspective provides a summary of how the development of high-throughput screening methods in a biosafety level 3 (BSL-3) environment at Southern Research Institute (SR) contributed to pandemic response efforts. The challenges encountered are described, including those of a technical nature as well as those of working under the pressures of an unpredictable virus and pandemic.","journal":"SLAS DISCOVERY","year":2024,"id":468026,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9404,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1144730,"name":"S K Sanders","orcid":null,"position":1,"is_corresponding":false},{"id":1099440,"name":"Melinda Sosa","orcid":"0009-0005-9137-3375","position":2,"is_corresponding":false},{"id":948562,"name":"Sara McKellip","orcid":null,"position":3,"is_corresponding":false},{"id":821429,"name":"N. Miranda Nebane","orcid":"0000-0002-5354-4875","position":4,"is_corresponding":false},{"id":684832,"name":"Yohanka Martinez-Gzegozewska","orcid":"0009-0005-1616-5576","position":5,"is_corresponding":false},{"id":1099439,"name":"Andrew J. Reece","orcid":"0009-0006-6943-065X","position":6,"is_corresponding":false},{"id":923505,"name":"Pedro Ruiz","orcid":"0000-0003-2083-9527","position":7,"is_corresponding":false},{"id":1099968,"name":"Anna Manuvakhova","orcid":null,"position":8,"is_corresponding":false},{"id":771062,"name":"Ling Zhai","orcid":null,"position":9,"is_corresponding":false},{"id":1301231,"name":"Brooke Warren","orcid":null,"position":10,"is_corresponding":false},{"id":1300858,"name":"A. Curry","orcid":"0009-0005-8112-0825","position":11,"is_corresponding":false},{"id":1104373,"name":"Qinghua Zeng","orcid":"0000-0003-0394-5395","position":12,"is_corresponding":false},{"id":924122,"name":"J. Robert Bostwick","orcid":null,"position":13,"is_corresponding":false},{"id":402565,"name":"Paige N. Vinson","orcid":"0000-0003-0285-3376","position":14,"is_corresponding":false},{"id":287612,"name":"Lynn Rasmussen","orcid":"0000-0001-6211-2364","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:05:19.071498Z","pmid":"38761981","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}