{"doi":"10.1016/j.semcdb.2023.02.003","title":"Apoptosis and beyond: A new era for programmed cell death in Caenorhabditis elegans","abstract":null,"journal":"Seminars in Cell & Developmental Biology","year":2024,"id":654388,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1446810,"name":"Rashna Sharmin","orcid":null,"position":1,"is_corresponding":false},{"id":1197552,"name":"Aladin Elkhalil","orcid":"0000-0002-1826-2506","position":2,"is_corresponding":false},{"id":464296,"name":"Piya Ghose","orcid":"0000-0001-5612-617X","position":3,"is_corresponding":false},{"id":545481,"name":"Olya Yarychkivska","orcid":"0000-0002-0048-1006","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Apoptosis and beyond: A new era for programmed cell death in Caenorhabditis elegans","abstract":"Programmed cell death (PCD) is crucial for normal development and homeostasis. Our first insights into the genetic regulation of apoptotic cell death came from in vivo studies in the powerful genetic model system of C. elegans. More recently, novel developmental cell death programs occurring both embryonically and post-embryonically, and sex-specifically, have been elucidated. Recent studies in the apoptotic setting have also shed new light on the intricacies of phagocytosis in particular. This review provides a brief historical perspective of the origins of PCD studies in C. elegans, followed by a more detailed description of non-canonical apoptotic and non-apoptotic death programs. We conclude by posing open questions and commenting on our outlook on the future of PCD studies in C. elegans, highlighting the importance of advanced imaging tools and the continued leveraging of C. elegans genetics both with classical and modern cutting-edge approaches.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36792437","pmcid":null,"openalex_id":"https://openalex.org/W4320481347","authors":[],"funders":[{"funder_name":"National Institute of General Medical Sciences","grant_id":"F32GM13601","title":null},{"funder_name":"Cancer Prevention and Research Institute of Texas","grant_id":"R35GM142489","title":null},{"funder_name":"Cancer Prevention and Research Institute of Texas","grant_id":"RR100091","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"F31 HD100091","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"F32 GM136010","title":null}],"total_grants":5,"fwci":0.5529,"citation_percentile":0.6367688,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":3}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1084952123000319?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1084952123000319?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.semcdb.2023.02.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36792437","host_type":"repository"}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","Phagocytosis and Immune Regulation","Nanoparticles: synthesis and applications","Animals","Caenorhabditis elegans","Apoptosis","Caenorhabditis elegans Proteins","Phagocytosis"],"mesh_terms":["Animals","Phagocytosis","Caenorhabditis elegans","Apoptosis","Caenorhabditis elegans Proteins"],"keywords":["Biology","Caenorhabditis elegans","Programmed cell death","Apoptosis","Cell biology","Computational biology","Genetics","Gene","Cancer","pruning","Lcd","Cce"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T06:20:11.551670Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}