{"doi":"10.1016/j.semcdb.2014.03.001","title":"The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis","abstract":null,"journal":"Seminars in Cell & Developmental Biology","year":2014,"id":597427,"datarank":0.6749714505495399,"base_score":4.499809670330265,"endowment":4.499809670330265,"self_citation_contribution":0.6749714505495399,"citation_network_contribution":0.0,"self_endowment_contribution":0.6749714505495399,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":89,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":22,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1530570,"name":"Jessica L. Myers","orcid":null,"position":1,"is_corresponding":false},{"id":1171403,"name":"Shawn B. Bratton","orcid":"0000-0003-2895-5020","position":2,"is_corresponding":false},{"id":711155,"name":"John H. Richburg","orcid":"0000-0001-6334-9777","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis","abstract":"The ubiquitination of proteins is a post-translational modification that was first described as a means to target misfolded or unwanted proteins for degradation by the proteasome. It is now appreciated that the ubiquitination of proteins also serves as a mechanism to modify protein function and cellular functions such as protein trafficking, cell signaling, DNA repair, chromatin modifications, cell-cycle progression and cell death. The ubiquitination of proteins occurs through the hierarchal transfer of ubiquitin from an E1 ubiquitin-activating enzyme to an E2 ubiquitin-conjugating enzyme and finally to an E3 ubiquitin ligase that transfers the ubiquitin to its target protein. It is the final E3 ubiquitin ligase that confers the substrate specificity for ubiquitination and is the focus of this review. Spermatogenesis is a complex and highly regulated process by which spermatogonial stem cells undergo mitotic proliferation and expansion of the diploid spermatogonial population, differentiate into spermatocytes and progress through two meiotic divisions to produce haploid spermatids that proceed through a final morphogenesis to generate mature spermatozoa. The ubiquitination of proteins in the cells of the testis occurs in many of the processes required for the progression of mature spermatozoa. Since it is the E3 ubiquitin ligase that recognizes the target protein and provides the specificity and selectivity for ubiquitination, this review highlights known examples of E3 ligases in the testis and the differing roles that they play in maintaining functional spermatogenesis.","is_dataset_classified":null,"base_score":4.499809670330265,"endowment":4.499809670330265,"datacite_reuse_total":22,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24632385","pmcid":"PMC4043869","openalex_id":"https://openalex.org/W2090041336","authors":[],"funders":[{"funder_name":"NIEHS NIH HHS","grant_id":"ES007784","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"R01 ES016591","title":null},{"funder_name":"NCI NIH HHS","grant_id":"CA129521","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"ES016591","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM096101","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"P30 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and proteasome pathways","Toxoplasma gondii Research Studies","Autophagy in Disease and Therapy","Animals","Humans","Intercellular Junctions","Male","Proteolysis","Signal Transduction","Spermatogenesis","Testis","Ubiquitin-Protein Ligases","Ubiquitination"],"mesh_terms":["Animals","Humans","Intercellular Junctions","Male","Spermatogenesis","Testis","Signal Transduction","Ubiquitin-Protein Ligases","Ubiquitination","Proteolysis"],"keywords":["Ubiquitin ligase","Biology","Ubiquitin","F-box protein","Cell biology","Ubiquitin-Protein Ligases","Ubiquitin-conjugating enzyme","DDB1","Proteasome","Cell division control protein 4","Deubiquitinating enzyme","Biochemistry","Spermatogenesis","Ubiquitination","E3 Ligase"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.24089144.v1","title":"Additional file 1 of Integrated analysis of the ubiquitination mechanism reveals the specific signatures of tissue and 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