{"doi":"10.1016/j.semcdb.2011.09.003","title":"A-to-I RNA editing: The “ADAR” side of human cancer","abstract":null,"journal":"Seminars in Cell & Developmental Biology","year":2012,"id":623440,"datarank":0.6937459219926407,"base_score":4.624972813284271,"endowment":4.624972813284271,"self_citation_contribution":0.6937459219926407,"citation_network_contribution":0.0,"self_endowment_contribution":0.6937459219926407,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":101,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1611204,"name":"Sara Tomaselli","orcid":null,"position":1,"is_corresponding":false},{"id":228967,"name":"Franco Locatelli","orcid":"0000-0002-7976-3654","position":2,"is_corresponding":false},{"id":461840,"name":"Angela Gallo","orcid":"0000-0003-0297-1807","position":3,"is_corresponding":false},{"id":1611203,"name":"Federica Galeano","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A-to-I RNA editing: The “ADAR” side of human cancer","abstract":"Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human diseases, including tumours. A-to-I RNA editing changes the nucleotide sequence of target RNAs, introducing A-to-I/G \"mutations\". Since ADAR enzymes catalyse this nucleotide conversion, their expression/activity is essential and finely regulated in normal cells. This review summarizes the available knowledge on A-to-I RNA editing in the cancer field, giving a new view on how ADARs may play a role in carcinogenesis.","is_dataset_classified":null,"base_score":4.624972813284271,"endowment":4.624972813284271,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21930228","pmcid":null,"openalex_id":"https://openalex.org/W1996713482","authors":[],"funders":[{"funder_name":"IG grant AIRC (Associazione Italiana per la Ricerca sul Cancro)","grant_id":"","title":null}],"total_grants":1,"fwci":3.2858,"citation_percentile":0.9292187,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":13},{"year":2014,"count":10},{"year":2015,"count":9},{"year":2016,"count":5},{"year":2017,"count":13},{"year":2018,"count":5},{"year":2019,"count":2},{"year":2020,"count":7},{"year":2021,"count":9},{"year":2022,"count":7},{"year":2023,"count":7},{"year":2024,"count":6},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S108495211100139X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S108495211100139X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.semcdb.2011.09.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21930228","host_type":"repository"}],"fields_of_study":["RNA regulation and disease","CRISPR and Genetic Engineering","RNA Research and Splicing","Adenosine Deaminase","Biocatalysis","Humans","Neoplasms","RNA Editing","RNA, Neoplasm","RNA-Binding Proteins"],"mesh_terms":["Adenosine Deaminase","Humans","Neoplasms","RNA, Neoplasm","RNA-Binding Proteins","RNA Editing","Biocatalysis"],"keywords":["ADAR","RNA editing","Biology","RNA","Carcinogenesis","APOBEC","Genetics","Computational biology","Cancer","Gene","Genome"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T23:46:28.976710Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}