{"doi":"10.1016/j.semcdb.2009.10.010","title":"Cancer associated fibroblasts in cancer pathogenesis","abstract":null,"journal":"Seminars in Cell & Developmental Biology","year":2010,"id":673157,"datarank":0.8979678007926658,"base_score":5.986452005284438,"endowment":5.986452005284438,"self_citation_contribution":0.8979678007926658,"citation_network_contribution":0.0,"self_endowment_contribution":0.8979678007926658,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":397,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1758781,"name":"Aubie K. 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Interactions between the tumor and these host cells, as well as autonomous qualities of the host cells themselves, might explain why tumors in people with histologically similar cancers often behave and respond differently to treatment. Cells of the tumor microenvironment, variously referred to as cancer stroma, reactive stroma or carcinoma-associated fibroblasts (CAF), exist in close proximity to the cancer epithelium. Both stromal and epithelial phenotypes co-evolve during tumorigenesis and it is now becoming clear that these stromal cells may not be the innocent bystanders they had been widely thought to be, but rather may be active contributors to carcinogenesis. Our group and others have shown the important role that CAF play in the progression of cancer. In this article we will address current trends in the study of the interactions between cancer stroma and tumor cells in different organs. We will also highlight perceived knowledge gaps and suggest research areas that need to be further explored to provide new targets for anticancer therapies.","is_dataset_classified":null,"base_score":5.986452005284438,"endowment":5.986452005284438,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19896548","pmcid":"PMC2823834","openalex_id":"https://openalex.org/W2029712941","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"U54 CA126505","title":null},{"funder_name":"NCI NIH HHS","grant_id":"U54 CA113007","title":null},{"funder_name":"NCI NIH HHS","grant_id":"T32 CA009592","title":null}],"total_grants":3,"fwci":8.3791,"citation_percentile":0.98430978,"influential_citations":0,"citation_trend":[{"year":2012,"count":22},{"year":2013,"count":36},{"year":2014,"count":28},{"year":2015,"count":35},{"year":2016,"count":34},{"year":2017,"count":28},{"year":2018,"count":22},{"year":2019,"count":29},{"year":2020,"count":24},{"year":2021,"count":26},{"year":2022,"count":16},{"year":2023,"count":25},{"year":2024,"count":18},{"year":2025,"count":9},{"year":2026,"count":7}],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2823834","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2823834","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1084952109002134?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1084952109002134?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.semcdb.2009.10.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19896548","host_type":"repository"}],"fields_of_study":["Cancer Cells and Metastasis","Cancer, Hypoxia, and Metabolism","Proteoglycans and glycosaminoglycans research"],"mesh_terms":["Animals","Cell Transformation, Neoplastic","Fibroblasts","Homeostasis","Humans","Mutation","Neoplasms","Signal Transduction","Disease Progression"],"keywords":["Biology","Stromal cell","Stroma","Carcinogenesis","Cancer","Cancer-Associated Fibroblasts","Tumor microenvironment","Cancer cell","Cancer research","Immunology","Genetics","Immunohistochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T12:33:21.256052Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}